Version 2.80

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP220368-7   SUMO-activating enzyme subunit 1 Ab
Small ubiquitin-like modifier 1 (SUMO-1) is one of four enzymes in the SUMO family which plays a key role in posttranslational protein modification. SUMO-1 consists of the SUMO-1 activating enzyme A subunit (SAE1) and the SUMO-1 activating enzyme B subunit (SAE2), which have molecular weights of 40kD and 90kD, respectively. The SUMO family has been associated with diseases such as rheumatoid arthritis and primary biliary cirrhosis. SAE1 and SAE2 have been found in patients with dermatomyositis (DM) associated with widespread skin involvement, dysphagia, and interstitial pneumonia. Patients with DM without these specific associated symptoms are typically anti-SAE antibody negative. PMID: 17763420 Source: Regenstrief LOINC , PMID: 17763420

Fully-Specified Name

Component
SUMO-activating enzyme subunit 1 Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Long Common Name
SUMO-activating enzyme subunit 1 Ab [Units/volume] in Serum by Line blot
Short Name
SAE1 Ab Ser Line blot-aCnc
Display Name
SUMO-activating enzyme subunit 1 Ab Line blot Qn (S)
Consumer Name Alpha Get Info
SUMO-activating enzyme subunit 1 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.68 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ενζυμική υπομονάδα 1 ενεργοποίησης SUMO Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης
Synonyms: ACnc Ενζυμική υπομονάδα 1 ενεργοποίησης SUMO
es-ES Spanish (Spain) subunidad 1 de la enzima activadora de SUMO Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Subunidad de enzima activadora de SUMO 1 Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FR French (France) SAE1 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) Enzima SUMO-attivante, subunità 1 Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Subunità 1 di enzima SUMO-attivante
nl-NL Dutch (Netherlands) SUMO-activerend enzym subeenheid 1 As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam SAE1
zh-CN Chinese (China) SUMO-活化酶亚基 1 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: Ⅰ Ab;自身抗体 I SUMO-活化酶亚单位 1;小泛素样修饰蛋白;泛素样小蛋白;小分子泛素样修饰蛋白;小分子泛素样修饰体蛋白;Small Ubiquitin-like Modifier proteins;SUMO proteins 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 化学酶 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 酵素 酶制剂 酶类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82439-1