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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP71719-6   U1 small nuclear ribonucleoprotein A
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

LOINC Names Get Info

Fully-Specified Name
U1 small nuclear ribonucleoprotein A Ab:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
U1 small nuclear ribonucleoprotein A Ab [Presence] in Serum by Line blot
Short Name
U1 snRNP-A Ab Ser Ql Line blot
Display Name
U1 small nuclear ribonucleoprotein A Ab Line blot Ql (S)
Consumer Name Alpha Get Info
U1 Small Nuclear Ribonucleoprotein A antibody, Blood

Part Model Get Info

  • Component
    U1 small nuclear ribonucleoprotein A Ab
    LP71701-4
    • Analyte
      U1 small nuclear ribonucleoprotein A Ab
      LP71701-4
      • Component Numerator
        U1 small nuclear ribonucleoprotein A Ab
        LP71701-4
        • Component Numerator Core
          U1 small nuclear ribonucleoprotein A
          LP71719-6
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
88883-4Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC GroupGroup Name
LG21924-2U1 small nuclear ribonucleoprotein A Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)U1 malý jaderný ribonukleoprotein A Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
de-ATGerman (Austria)Synonyms: U1-snRNP-A-AK ql. IA
de-DEGerman (Germany)U1 kleine nukleäre Ribonukleoprotein-A Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Line-Blot
el-GRGreek (Greece)Μικρή πυρηνική ριβονουκλεοπρωτεΐνη A Αντίσωμα:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: A Ord PrThr Pt SERO Αντίσωμα Γραμμή κηλίδωσης Μικρή πυρηνική ριβονουκλεοπρωτεΐνη A Μικρή πυρηνική ριβονουκλεοπρωτεΐνη U1 Ορός Πυρηνικό
es-ESSpanish (Spain)U1 ribonucleoproteína nuclear pequeña A Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)U1 ribonucleoproteína nuclear sub A Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CAFrench (Canada)Petite particule nucléaire ribonucléoprotéique U1 A, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)U1 RNP A Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)U1, piccola ribonucleoproteina nucleare A Ab:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 A Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)u1 small nucleair ribonucleoproteïne A As:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)U1 mała jądrowa rybonukleoproteina A Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:line blot
Synonyms: Mała rybonukleoproteina jądrowa U1 Przeciwciała do bogatej w urydynę małej jądrowej nukleoproteiny A U1-snRNP A
zh-CNChinese (China)U1 小细胞核核糖核蛋白 A 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: A 型 A 型抗体 Ab;自身抗体 RNP snRNP U1 RNP A;U1 snRNP A;U1 小细胞核核糖核蛋白 A;U1 small nuclear ribonucleoprotein A;U1RNP A U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 小分子核糖核蛋白体 小分子细胞核核糖核蛋白 小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP） 时刻;随机;随意;瞬间 核;胞核 核内小核糖核蛋白 核微小核糖核蛋白 核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP） 核蛋白 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
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