LOINC
Version 2.67

82474-8Borrelia mayonii oppA1 gene [Presence] in Unspecified specimen by NAA with non-probe detectionActive

Term Description

The DNA amplification target is the 283-bp plasminogen-binding protein gene (oppA1), which is present at a frequency of one copy per organism in all four pathogenic species of the Borrelia burgdorferi sensu lato genogroup (Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii, and Borrelia mayonii). Melting curve analysis is used to identify B. mayonii and differentiate it from the other three species. Potential specimens include CSF, tissue and synovial fluid.
Source: Regenstrief LOINC

Part Descriptions

LP220481-8   Borrelia mayonii (oppA1) gene
Borrelia mayonii is the proposed name for a bacterial species found in 2013, causing Lyme disease in six people who live in the upper Midwestern United States. Worldwide, Lyme disease is caused by three main species of bacteria: Borrelia burgdorferi, B. afzelii, and B. garinii. Borrelia burgdorferi causes Lyme disease in the United States, while the other two species are the leading causes of Lyme disease in Europe and Asia. B. mayonii is a new species that is genetically distinct from these three species and is the only species besides B. burgdorferi shown to cause Lyme disease in North America. B. mayonii has been identified in blacklegged (or "deer") ticks collected in several counties in northwestern Wisconsin and Minnesota. It is highly likely, however, that infected ticks occur in other areas of both states. Limited information suggests that illness caused by B. mayonii is similar to that caused by B. burgdorferi, but with a few possible differences. Like B. burgdorferi, B. mayonii causes fever, headache, rash, and neck pain in the early stages of infection (days after exposure) and arthritis in later stages of infection (weeks after exposure). Unlike B. burgdorferi however, B. mayonii appears to be associated with nausea and vomiting, diffuse rashes, and a higher concentration of bacteria in the blood. Patients infected with B. mayonii have been successfully treated with a 2-4 week course of doxycycline. Amoxicillin, ceftriaxone, and cefuroxime have also been used. Source: Centers for Disease Control and Prevention, CDC: Borrelia mayonii

LP220481-8   Borrelia mayonii (oppA1) gene
The oppA1 gene is a member of a family of three genes; oppA-1, oppA-2, and oppA-3, that encode predicted peptide-binding proteins. Peptide-binding protein dependent transport systems are recognized to play important roles in microbial cell signaling and virulence. [PMID: 9712756] Source: Regenstrief LOINC

Fully-Specified Name

Component
Borrelia mayonii (oppA1) gene
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Short Name
B mayonii (oppA1) XXX Ql NAA+non-probe
Display Name
B. mayonii oppA1 gene NAA+non-probe Ql (Unsp spec)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.65
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG41633-5 Borrelia

Language Variants Get Info

zh-CNChinese (CHINA)
梅奥疏螺旋体 (oppA1) 基因:存在情况或阈值:时间点:XXX:序数型:非探针法.基因扩增.靶向
fr-FRFrench (FRANCE)
Borrelia mayonii oppA1 gène:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Non-PCR amplification de cible
it-ITItalian (ITALY)
Borrelia mayonii (oppA1), gene:PrThr:Pt:XXX:Ord:Non-sonda.amp.tar
es-ESSpanish (SPAIN)
Gen oppA1 de Borrelia mayonii:PrThr:Punto temporal:XXX:Ord:Amplificación del objetivo no basado en sonda

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82474-8