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Term Description

This assay represents the fraction of T-cell receptor beta chain variable gene segments that are in the TRBV28 gene family out of the total number of TRBV gene segments identified ("diversity ratio"). At the time this term was created, TRBV28 did not contain any subtypes. Because some portion of TRBV gene segments that are counted in the total will not correspond to any of the probes and therefore will not be identified as belonging to a specific TRBV gene family, the total of the diversity ratios reported will not equal 100%.

Part Description

LP220311-7   TRBV28 gene segment
The T-cell receptor (TCR) is a cell-surface receptor that is composed of two polypeptide chains that are linked by a disulfide bond. In peripheral T-cells, approximately 85% of TCR consist of an alpha and beta chain, while the rest have gamma and delta. TCRs have multiple domains including constant (C), variable (V), joining (J) and diversity (D) domains. The TCR beta gene locus (TRB) is located on chromosome 7q34 and includes nearly 70 V genes that are grouped into families ("TRBV families") based upon greater than 75% nucleotide sequence identity. During T-cell development in the thymus, V, D, and J segments undergo somatic rearrangement to form complete V domain exons that are responsible for antigen recognition. The diversity of the T-cell repertoire depends on recombination as well as nucleotide insertion and deletion at junctional sites (V-J, D-J, and V-D). PMID: 12499424 Although nearly 70 TRBV gene segments have been identified, studies have shown that the total number of functional TRBV gene segments expressed by a healthy individual varies from 42 to 47 due to 7 frequently occurring inactivating polymorphisms and a large insertion/deletion-related polymorphism encompassing 2 TRBV gene segments. PMID: 12493004 TRBV repertoire analysis is used to determine the number of gene segments and their relative frequency as expressed by an individual. The total number of gene segments present is identified based on various techniques including fragment length analysis, and specific probes are used to identify a common set of gene segments. From these data, the diversity ratio is calculated as the relative number of gene segments from a particular gene family compared to the total. Because some portion of gene segments that are counted in the total will not correspond to any of the probes and therefore will not be identified as belonging to a specific TRBV gene family, the total of the diversity ratios reported will not equal 100%. Analysis of the TRBV repertoire, including the number of gene families present and their relative proportions can be used to evaluate primary immunodeficiencies, monitor immune reconstitution after hematopoietic steam cell transplantation, and assess temporal repertoire changes in autoimmune diseases and viral infections. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
TRBV28 gene segment/TRBV gene segments.total:NFr:Pt:Bld:Qn:
Long Common Name
TRBV28 gene segment/TRBV gene segments.total in Blood
Short Name
TRBV28 seg/TRBV seg total NFr Bld
Display Name
TRBV28 gene segment/TRBV gene segments.total (Bld)
Consumer Name Alpha Get Info
TRBV28 gene segment/TRBV gene Segments.total, Blood

Part Model Get Info

  • Component
    TRBV28 gene segment/TRBV gene segments.total
    LP287292-9
    • Analyte
      TRBV28 gene segment/TRBV gene segments.total
      LP287292-9
      • Component Numerator
        TRBV28 gene segment
        LP220311-7
        • Component Numerator Core
          TRBV28 gene segment
          LP220311-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        TRBV gene segments.total
        LP220284-6
        • Component Denominator Core
          TRBV gene segments.total
          LP220284-6
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NFr
    LP6838-9
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Segmenty genu TRBV28/segmenty genu TRBV.celkem:Početní podíl:Časový bod:Krev:Kvantitativní:
el-GRGreek (Greece)Τμήματα γονιδίου TRBV28/Τμήματα γονιδίου TRBV.σύνολο:NFr:Pt:Αίμα:Qn:
Synonyms: MOLPATH NFr Pt Qn Αίμα Γονίδιο Τμήματα γονιδίου TRBV.σύνολο Τμήματα γονιδίου TRBV28
es-ESSpanish (Spain)Segmento del gen TRBV28/Segmentos del gen TRBV:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Segmento del gen TRBV28 / segmentos del gen TRBV total:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FRFrench (France)TRBV28 gène segment/TRBV gène segments totaux:Fraction de nombres:Ponctuel:Sang:Numérique:
it-ITItalian (Italy)TRBV28, segmento gene/TRBV, segmenti gene.totale:NFr:Pt:Sangue:Qn:
Synonyms: Frazione numerica Patologia molecolare Punto nel tempo (episodio) Sangue Segmento gene TRBV28 Totale segmenti gene TRBV
pl-PLPolish (Poland)TRBV28 gen segment/segmenty genów TRBV, całkowite:frakcja liczbowa:punkt w czasie:krew:ilościowy:
Synonyms: Segment genu TRBV28
zh-CNChinese (China)TRBV28 基因片段/TRBV 基因片段类.总计:计数型分数:时间点:全血:定量型:
Synonyms: TRBV 基因片段类（片段、节段、段）.总计;T 细胞受体 Beta 可变区基因片段;T-细胞受体β可变区基因片段;T Cell Receptor Beta Variable gene segment TRBV28 基因片段（节段、段）;T 细胞受体 Beta 可变区 28 (基因/假基因) 基因片段;T-细胞受体β可变区 28 (基因/假基因) 基因片段;T Cell Receptor Beta Variable 28 (Gene/Pseudogene) gene segment 全体数量 全部 共计 分子病理学;分子病理学试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总量 总额 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 汇总 血;血液 遗传基因;遗传因子;吉恩;生物基因

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82481-3