82499-5

TRBV4 gene segments/TRBV gene segments.total in Blood

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Term Description

This assay represents the fraction of T-cell receptor beta chain variable gene segments that are in the TRBV4 gene family out of the total number of TRBV gene segments identified ("diversity ratio"). At the time this term was created, TRBV4 included the following gene segments: TRBV4-1, TRBV4-2, and TRBV4-3. Because some portion of TRBV gene segments that are counted in the total will not correspond to any of the probes and therefore will not be identified as belonging to a specific TRBV gene family, the total of the diversity ratios reported will not equal 100%.

Part Description

LP220330-7 TRBV4 gene segments
The T-cell receptor (TCR) is a cell-surface receptor that is composed of two polypeptide chains that are linked by a disulfide bond. In peripheral T-cells, approximately 85% of TCR consist of an alpha and beta chain, while the rest have gamma and delta. TCRs have multiple domains including constant (C), variable (V), joining (J) and diversity (D) domains. The TCR beta gene locus (TRB) is located on chromosome 7q34 and includes nearly 70 V genes that are grouped into families ("TRBV families") based upon greater than 75% nucleotide sequence identity. During T-cell development in the thymus, V, D, and J segments undergo somatic rearrangement to form complete V domain exons that are responsible for antigen recognition. The diversity of the T-cell repertoire depends on recombination as well as nucleotide insertion and deletion at junctional sites (V-J, D-J, and V-D). PMID: 12499424 Although nearly 70 TRBV gene segments have been identified, studies have shown that the total number of functional TRBV gene segments expressed by a healthy individual varies from 42 to 47 due to 7 frequently occurring inactivating polymorphisms and a large insertion/deletion-related polymorphism encompassing 2 TRBV gene segments. PMID: 12493004 TRBV repertoire analysis is used to determine the number of gene segments and their relative frequency as expressed by an individual. The total number of gene segments present is identified based on various techniques including fragment length analysis, and specific probes are used to identify a common set of gene segments. From these data, the diversity ratio is calculated as the relative number of gene segments from a particular gene family compared to the total. Because some portion of gene segments that are counted in the total will not correspond to any of the probes and therefore will not be identified as belonging to a specific TRBV gene family, the total of the diversity ratios reported will not equal 100%. Analysis of the TRBV repertoire, including the number of gene families present and their relative proportions can be used to evaluate primary immunodeficiencies, monitor immune reconstitution after hematopoietic steam cell transplantation, and assess temporal repertoire changes in autoimmune diseases and viral infections. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: TRBV4 gene segments/TRBV gene segments.total:NFr:Pt:Bld:Qn:
Long Common Name: TRBV4 gene segments/TRBV gene segments.total in Blood
Short Name: TRBV4 seg/TRBV seg total NFr Bld
Display Name: TRBV4 gene segments/TRBV gene segments.total (Bld)
Consumer Name Alpha Get Info: TRBV4 gene segments/TRBV gene Segments.total, Blood

Part Model Get Info

Component
TRBV4 gene segments/TRBV gene segments.total
LP287296-0
- Analyte
  TRBV4 gene segments/TRBV gene segments.total
  LP287296-0
  - Component Numerator
    TRBV4 gene segments
    LP220330-7
    - Component Numerator Core
      TRBV4 gene segments
      LP220330-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    TRBV gene segments.total
    LP220284-6
    - Component Denominator Core
      TRBV gene segments.total
      LP220284-6
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NFr
LP6838-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld
LP7057-5
- System Core
  Bld
  LP7057-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: MOLPATH
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.58 (ADD)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Segmenty genu TRBV4/segmenty genu TRBV.celkem:Početní podíl:Časový bod:Krev:Kvantitativní:
el-GR	Greek (Greece)	Τμήματα γονιδίου TRBV4/Τμήματα γονιδίου TRBV.σύνολο:NFr:Pt:Αίμα:Qn: Synonyms: MOLPATH NFr Pt Qn Αίμα Γονίδιο Τμήματα γονιδίου TRBV.σύνολο Τμήματα γονιδίου TRBV4
es-ES	Spanish (Spain)	Segmentos del gen TRBV4/Segmentos del gen TRBV:Fracción numérica:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Segmentos del gen TRBV4 / segmentos del gen TRBV total:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	TRBV4 gène segments/TRBV gène segments totaux:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	TRBV4, segmenti gene/TRBV, segmenti gene.totale:NFr:Pt:Sangue:Qn: Synonyms: Frazione numerica Patologia molecolare Punto nel tempo (episodio) Sangue Segmenti gene TRBV4 Totale segmenti gene TRBV
pl-PL	Polish (Poland)	TRBV4 gen segmenty/segmenty genów TRBV, całkowite:frakcja liczbowa:punkt w czasie:krew:ilościowy: Synonyms: Segmenty genu TRBV4
zh-CN	Chinese (China)	TRBV4 基因片段类/TRBV 基因片段类.总计:计数型分数:时间点:全血:定量型: Synonyms: TRBV 基因片段类（片段、节段、段）.总计;T 细胞受体 Beta 可变区基因片段;T-细胞受体β可变区基因片段;T Cell Receptor Beta Variable gene segment TRBV4 基因片段类（片段、节段、段）;T 细胞受体 Beta 可变区 4 (基因/假基因) 基因片段;T-细胞受体β可变区 4 (基因/假基因) 基因片段;T Cell Receptor Beta Variable 4 (Gene/Pseudogene) gene segment 全体数量全部共计分子病理学;分子病理学试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺总总和总数总量总额数量型分数;数量或计数型分数;数量型分数或计数型分数时刻;随机;随意;瞬间汇总血;血液遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit	Source
%	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.