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Part Description

LP264987-1   Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control:RelACnc:Pt:Bld MC:Qn:
Long Common Name
Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Short Name
NK cytotox.25:1 E:T/Pos cntrl Bld MC
Display Name
NK cytotoxicity 25:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
Consumer Name Alpha Get Info
NK cytotoxicity 25:1 E:T ratio/Positive Control, Blood

Part Model Get Info

  • Component
    Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control
    LP286620-2
    • Analyte
      Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control
      LP286620-2
      • Component Numerator
        Natural killer cell cytotoxicity.25:1 effector to target cell ratio
        LP230184-6
        • Component Numerator Core
          Natural killer cell cytotoxicity.25:1 effector to target cell ratio
          LP230184-6
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Positive control
        LP204182-2
        • Component Denominator Core
          Positive control
          LP204182-2
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    RelACnc
    LP35077-4
  • Time
    Pt
    LP6960-1
  • System
    Bld MC
    LP193850-7
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.63 (MIN)
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
82720-4Natural killer cell cytotoxicity panel - Blood mononuclear cells

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Buňky NK cytotoxicita.poměr efektoru k cílové buňce 25:1/pozitivní kontrola:Relativní arbitrární koncentrace:Časový bod:Buňky krevní mononukleární:Kvantitativní:
el-GRGreek (Greece)Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 25:1/Θετικός μάρτυρας:RelACnc:Pt:Αίμα Μονοπύρηνα κύτταρα:Qn:
Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 25:1
es-ESSpanish (Spain)Citotoxicidad de las células Natural killer. Proporción efector con célula diana 25: 1/Control positivo:Concentración arbitraria relativa:Punto temporal:Celulas Mononucleares sanguíneas:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Citotoxicidad de las células asesinas naturales 25:1 relación entre el efector y la célula diana / Control positivo:Concentración relativa arbitraria:Punto temporal:Células mononucleares de sangre:Cuantitativo
fr-FRFrench (France)Cytotoxicité cellules NK Patient 25/1/contrôle positfif:Activité arbitraire relative:Ponctuel:Cellules mononucléées de sang périphérique:Numérique:
it-ITItalian (Italy)Cellula natural killer, citotossicità.rapporto 25:1 effettore verso cellula target/Controllo positivo:RelACnc:Pt:Cellule mononucleate da sangue intero:Qn:
Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue
zh-CNChinese (China)自然杀伤细胞细胞毒性.25:1 效应细胞-靶细胞比值/阳性对照:相对任意型浓度:时间点:全血单个核细胞:定量型:
Synonyms: Ⅰ I 全血（血液、血）单个核细胞（单核细胞、MC）;全血标本（样品、样本、试样）单个核细胞 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 相对任意浓度;相对型任意浓度;相对人工型浓度 结果阳性 自然杀伤细胞（NK细胞）细胞毒性.25:1 效应细胞-靶细胞比值（比例、比、比率） 血;血液 血液学/细胞计数;血液学与细胞计数 试验阳性 试验阳性的 阳性对照（对照品、对照样品、对照样本、对照试样、对照标本、对照标准、参照、参照品） 阳性结果

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82727-9