82857-4

Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone [Molar ratio] in 24 hour Urine

Active

Term Description

The quantitative ratios of various steroids in urine are measured to diagnose conditions such as 17-alpha-, 21-, and 11-beta hydroxylase deficiencies, pseudohypoaldosteronismus, 3-beta hydroxysteroid dehydrogenase deficiency, corticosterone methyl oxidase deficiency, 11-beta hydroxysteroid dehydrogenase types 1 and 2 deficiency, and 5-alpha reductase deficiency. The results along with clinical symptoms and past medical history are used for the assessment and treatment of the associated deficiency or condition. Below are examples of various disorders and their associated urinary findings:
1. 17-alpha hydroxylase deficiency: (THA+THB+5aTHB)/(THE+THF+5aTHF) > 10, (THA+THB+5aTHB)/(AN+ET) > 10.
2. 21-hydroxylase deficiency: 17HP/(THE+THF+5aTHF) > 0.25, PT/(THE+THF+5aTHF) > 0.25.
3. 11-beta HSD2 deficiency: (THF+5aTHF)/THE > 3
4. 11-beta HSD1 deficiency: (THF+5aTHF)/THE < 0.1
5. 11-beta hydroxylase deficiency: 100*THS/(THE+THF+5aTHF) > 10, 100*THDOC/(THE+THF+5aTHF) > 10
6. Pseudohypoaldosteronismus: 100*THALDO/(THE+THF+5aTHF) > 5
7. 5-alpha reductase: ET/AN > 5, THF/5aTHF > 10
Where AN = Androsterone, ET= etiocholanolone, 17HP= metabolites of 17-OH-progesterone (pregnandiol, pregnantriol, 17-OH-pregnanolone), THA = tetrahydro compound A, THB = tetrahydrocorticosterone, 5aTHB =5 alpha tetrahydrocorticosterone, THE = tetrahydrocortisone, THF = Tetrahydrocortisone, 5aTHF = 5a-tetrahydrocortisone or Allo-tetrahydrocortisone, THS = tetrahydrodeoxycortisol, THALDO = tetrahydroaldosterone, and THDOC =tetrahydrodeoxycortisone
[NLM Catalog ID: 101631718]
Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone:SRto:24H:Urine:Qn:
Long Common Name: Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone [Molar ratio] in 24 hour Urine
Short Name: THF+5a-THC/THE 24h Ur-sRto
Display Name: Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone (24H U) [Molar ratio]
Consumer Name Alpha Get Info: Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone, Urine

Part Model Get Info

Component
Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone
LP287218-4
- Analyte
  Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone
  LP287218-4
  - Component Numerator
    Tetrahydrocortisol+5-alpha tetrahydrocortisol
    LP230263-8
    - Component Numerator Core
      Tetrahydrocortisol+5-alpha tetrahydrocortisol
      LP230263-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Tetrahydrocortisone
    LP230264-6
    - Component Denominator Core
      Tetrahydrocortisone
      LP230264-6
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SRto
LP6868-6
Time
24H
LP6924-7
- Time Core
  24H
  LP6924-7
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.82 (NAM)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
73885-6	Steroid fractions panel - 24 hour Urine

Member of these Groups Get Info

LOINC Group	Group Name
LG37435-1	Tetrahydrocortisol+5-alpha tetrahydrocortisol/Tetrahydrocortisone\|SRto\|Urine

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Tetrahydrokortizol+allo-tetrahydrokortizol/tetrahydrokortizon:Látkový poměr:24 hodin:Moč:Kvantitativní:
el-GR	Greek (Greece)	Τετραϋδροκοτιζόλη+αλλο-τετραϋδροκοτιζόλη/Τετραϋδροκορτιζόνη:SRto:24H:Ούρα:Qn: Synonyms: 24H 5-α-τετραϋδροκορτιζόλη CHEM Qn SRto Ούρα Τετραϋδροκορτιζόλη Τετραϋδροκορτιζόνη Τετραϋδροκοτιζόλη+αλλο-τετραϋδροκοτιζόλη
es-ES	Spanish (Spain)	Tetrahidrocortisol+alo-tetrahidrocortisol/Tetrahidrocortisona:Relacion de Sustancia:24 horas:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Tetrahidrocortisol + alo-tetrahidrocortisol / tetrahidrocortisona:Proporción de sustancia:24H:Orina:Cuantitativo:
fr-FR	French (France)	Tetrahydrocortisol+allo-tétrahydrocortisol/tétrahydrocortisone:Moles ratio:24H:Urine:Numérique:
it-IT	Italian (Italy)	Tetraidrocortisolo+allo-tetraidrocortisolo/Tetraidrocortisone:Srto:24h:Urine:Qn: Synonyms: 24 Ore Chimica Rapporto di sostanza
nl-NL	Dutch (Netherlands)	tetrahydrocortisol + allo-tetrahydrocortisol/tetrahydrocortison:molaire verhouding:24 uur:urine:kwantitatief: Synonyms: 24U
pl-PL	Polish (Poland)	Tetrahydrokortyzol+allo-tetrahydrokortyzol/tetrahydrokortyzon:współczynnik molowy:24h:mocz:ilościowy: Synonyms: 24 godziny Tetrahydrokortyzol i allo-tetrahydrokortyzol
zh-CN	Chinese (China)	四氢皮质醇+别-四氢皮质醇/四氢可的松:物质的量比率:24小时:尿液:定量型: Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 5 Alpha-四氢皮质甾醇 5 Alpha-四氢皮醇 5-A 四氢皮质醇;5-α 四氢皮质醇;5-alpha（α、A）四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇） 5α-四氢皮质甾醇 5α-四氢皮质醇 5α-四氢皮醇 THC;THF;四氢皮质甾醇;四氢皮醇 α 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇）+别-四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇）四氢考的松尿;小便;下泉物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值阿尔法

Example Units

Unit	Source
{ratio}	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.