82896-2

Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol [Molar ratio] in Urine

Active

Term Description

The quantitative ratios of various steroids in urine are measured to diagnose conditions such as 17-alpha-, 21-, and 11-beta hydroxylase deficiencies, pseudohypoaldosteronismus, 3-beta hydroxysteroid dehydrogenase deficiency, corticosterone methyl oxidase deficiency, 11-beta hydroxysteroid dehydrogenase types 1 and 2 deficiency, and 5-alpha reductase deficiency. The results along with clinical symptoms and past medical history are used for the assessment and treatment of the associated deficiency or condition. Below are examples of various disorders and their associated urinary findings:
1. 17-alpha hydroxylase deficiency: (THA+THB+5aTHB)/(THE+THF+5aTHF) > 10, (THA+THB+5aTHB)/(AN+ET) > 10.
2. 21-hydroxylase deficiency: 17HP/(THE+THF+5aTHF) > 0.25, PT/(THE+THF+5aTHF) > 0.25.
3. 11-beta HSD2 deficiency: (THF+5aTHF)/THE > 3
4. 11-beta HSD1 deficiency: (THF+5aTHF)/THE < 0.1
5. 11-beta hydroxylase deficiency: 100*THS/(THE+THF+5aTHF) > 10, 100*THDOC/(THE+THF+5aTHF) > 10
6. Pseudohypoaldosteronismus: 100*THALDO/(THE+THF+5aTHF) > 5
7. 5-alpha reductase: ET/AN > 5, THF/5aTHF > 10
Where AN = Androsterone, ET= etiocholanolone, 17HP= metabolites of 17-OH-progesterone (pregnandiol, pregnantriol, 17-OH-pregnanolone), THA = tetrahydro compound A, THB = tetrahydrocorticosterone, 5aTHB =5 alpha tetrahydrocorticosterone, THE = tetrahydrocortisone, THF = Tetrahydrocortisone, 5aTHF = 5a-tetrahydrocortisone or Allo-tetrahydrocortisone, THS = tetrahydrodeoxycortisol, THALDO = tetrahydroaldosterone, and THDOC =tetrahydrodeoxycortisone
[NLM Catalog ID: 101631718]
Source: Regenstrief LOINC

Part Description

LP188448-7 Pregnanediolone
Pregnanediolone (PDL) is, among other steroids like pregnanetriol (P3), an important marker in the urinary steroid excretion profile for the occurrence of an adrenal 21-hydroxylase-deficiency. Its concentration is also an indication for the effectiveness of medication (e.g., cortisol supplementation) against this disease. PMID: 10399855 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol:SRto:Pt:Urine:Qn:
Long Common Name: Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol [Molar ratio] in Urine
Short Name: PDL/THE+THF+5a-THF Ur-sRto
Display Name: Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol (U) [Molar ratio]
Consumer Name Alpha Get Info: Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha Tetrahydrocortisol, Urine

Part Model Get Info

Component
Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol
LP286888-5
- Analyte
  Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol
  LP286888-5
  - Component Numerator
    Pregnanediolone
    LP188448-7
    - Component Numerator Core
      Pregnanediolone
      LP188448-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol
    LP230218-2
    - Component Denominator Core
      Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol
      LP230218-2
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SRto
LP6868-6
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.58 (ADD)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
73886-4	Steroid fractions panel - Urine

Member of these Groups Get Info

LOINC Group	Group Name
LG37446-8	Pregnanediolone/Tetrahydrocortisone+tetrahydrocortisol+5-alpha tetrahydrocortisol\|SRto\|Urine

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Pregnandiolon/tetrahydrokortizon+tetrahydrokortizol+5-alfa-tetrahydrokortizol:Látkový poměr:Časový bod:Moč:Kvantitativní:
el-GR	Greek (Greece)	Πρεγνανοδιόνη/Τετραϋδροκορτιζόνη+τετραϋδροκορτιζόλη+5-α τετραϋδροκορτιζόλη:SRto:Pt:Ούρα:Qn: Synonyms: 5-α-τετραϋδροκορτιζόλη CHEM Pt Qn SRto Ούρα Πρεγνανοδιόνη Τετραϋδροκορτιζόλη Τετραϋδροκορτιζόνη Τετραϋδροκορτιζόνη+τετραϋδροκορτιζόλη+5-α τετραϋδροκορτιζόλη Τετραϋδροκοτιζόλη+αλλο-τετραϋδροκοτιζόλη
es-ES	Spanish (Spain)	Pregnanelodiona/Tetrahidrocortisona+tetrahidrocortisol+5-alfa-tetrahidrocortisol:Relacion de Sustancia:Punto temporal:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Pregnanediolona / Tetrahidrocortisona + tetrahidrocortisol + 5-alfa tetrahidrocortisol:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-FR	French (France)	Pregnanediolone/tétrahydrocortisone+tétrahydrocortisol+5-alpha tétrahydrocortisol:Moles ratio:Ponctuel:Urine:Numérique:
it-IT	Italian (Italy)	Pregnanediolone/Tetraidrocortisone+tetraidrocortisolo+5-alfa tetraidrocortisolo:Srto:Pt:Urine:Qn: Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NL	Dutch (Netherlands)	pregnaandiolon/tetrahydrocortison + tetrahydrocortisol + 5-alfa tetrahydrocortisol:molaire verhouding:moment:urine:kwantitatief:
zh-CN	Chinese (China)	孕烷二醇酮/四氢可的松+四氢皮质醇+5-alpha 四氢皮质醇:物质的量比率:时间点:尿液:定量型: Synonyms: 5 Alpha-四氢皮质甾醇 5 Alpha-四氢皮醇 5-A 四氢皮质醇;5-α 四氢皮质醇;5-alpha（α、A）四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇） 5α-四氢皮质甾醇 5α-四氢皮质醇 5α-四氢皮醇 THC;THF;四氢皮质甾醇;四氢皮醇 α 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺四氢可的松（四氢考的松）+四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇）+5-alpha（α、A）四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇）;四氢可的松+四氢皮质醇+5-α四氢皮质醇四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇）+别-四氢皮质醇（THC、THF、四氢皮质甾醇、四氢皮醇）四氢考的松孕甾二醇酮;娠烷二醇酮;Pregnanediolone 尿;小便;下泉时刻;随机;随意;瞬间物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值阿尔法

Example Units

Unit	Source
{ratio}	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.