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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

LOINC Names Get Info

Fully-Specified Name
Jo-1 extractable nuclear Ab.IgG:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
Jo-1 extractable nuclear IgG Ab [Presence] in Serum by Line blot
Short Name
ENA Jo1 IgG Ser Ql Line blot
Display Name
Jo-1 extractable nuclear IgG Line blot Ql (S)
Consumer Name Alpha Get Info
Jo-1 extractable nuclear IgG antibody, Blood

Part Model Get Info

  • Component
    Jo-1 extractable nuclear Ab.IgG
    LP38742-0
    • Analyte
      Jo-1 extractable nuclear Ab.IgG
      LP38742-0
      • Component Numerator
        Jo-1 extractable nuclear Ab.IgG
        LP38742-0
        • Component Numerator Core
          Jo-1 extractable nuclear
          LP16719-4
        • Component Numerator Core Suffix
          Ab.IgG
          LP32401-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG17624-4Jo-1 extractable nuclear Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Antinukleární protilátky IgG Jo-1 extrahovatelné:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
de-DEGerman (Germany)Jo-1 extrahierbarer nukleärer Ak.IgG:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Line-Blot
Synonyms: Jo-1
el-GRGreek (Greece)εκχυλίσιμα πυρηνικά αντιγόνα Jo-1 Αντισώματα IgG:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γραμμή κηλίδωσης Εκχυλίσιμα πυρηνικά εκχυλίσιμα πυρηνικά αντιγόνα Jo-1 Ορός Πυρηνικό
es-ESSpanish (Spain)Jo-1 IgG:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)Ab.IgG nuclear extraíble con Jo-1:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CAFrench (Canada)Jo-1 nucléaire soluble, IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)Jo-1 Ac IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)Jo-1, nucleare estraibile Ab.IgG:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpi IgG anticorpo ENA Jo1 Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)jo-1 extraheerbaar nucleair As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Jo-1 rozpuszczalny jądrowy Ab.IgG:granica wykrywalności:punkt w czasie:surowica:uporządkowany:line blot
Synonyms: IgG Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 przeciwciała IgG Przeciwciała IgG do jądra komórkowego Przeciwciała IgG do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe
zh-CNChinese (China)Jo-1 可提取性核 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ⅰ Ab.IgG;IgG;抗体 IgG Ab;自身抗体 ANA ENA Ab ENA Jo1 Ab ENA Jo-1 Ab ENA Jo1 Ab.IgG ENA Jo-1 Ab.IgG ENA Jo1 IgG ENA Jo-1 IgG ENA Jo1 抗体 ENA Jo-1 抗体 ENA Jo1 抗体.IgG ENA Jo-1 抗体.IgG ENA Jo1;ENA Jo-1;Jo-1 可提取性核 Ag;Jo-1 可提取性核抗原;可提取性核 Ag Jo1;可提取性核 Ag Jo-1;可提取性核抗原 Jo1;可提取性核抗原 Jo-1;组氨酰-tRNA 合成酶;组氨酰基-tRNA 合成酶 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 I Jo1 可提取性核 Ab Jo-1 可提取性核 Ab Jo1 可提取性核 Ab.IgG Jo-1 可提取性核 Ab.IgG Jo1 可提取性核 Ag Ab Jo-1 可提取性核 Ag Ab Jo1 可提取性核 Ag Ab.IgG Jo-1 可提取性核 Ag Ab.IgG Jo1 可提取性核抗体 Jo1 可提取性核抗体.IgG Jo1 可提取性核抗原 抗体 Jo-1 可提取性核抗原 抗体 Jo1 可提取性核抗原 抗体.IgG Jo-1 可提取性核抗原 抗体.IgG NA 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 可提取性核 Ab 可提取性核 Ag Jo1 Ab 可提取性核 Ag Jo-1 Ab 可提取性核 Ag Jo1 Ab.IgG 可提取性核 Ag Jo-1 Ab.IgG 可提取性核 Ag 之 Ab 可提取性核抗原 Jo1 IgG 可提取性核抗原 Jo-1 IgG 可提取性核抗原 Jo1 抗体 可提取性核抗原 Jo-1 抗体 可提取性核抗原 Jo1 抗体.IgG 可提取性核抗原 Jo-1 抗体.IgG 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 核心抗体IgG 核心抗原抗体.IgG 核心抗原抗体IgG 核抗体.IgG 核抗体IgG 核抗原抗体.IgG 核抗原抗体IgG 线点杂交技术;线点杂交法;线条状印迹法 细胞核 Ab 细胞核 Ab.IgG 细胞核 IgG 胞核 Ab 胞核 Ab.IgG 胞核抗体 胞核抗体.IgG 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82918-4