82924-2
PL-7 IgG Ab [Presence] in Serum by Immunoassay
Active
Part Description
LP30804-6 PL-7
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes.
Source: Regenstrief LOINC, PMID: 23573256
Fully-Specified Name
- Component
- Pl-7 Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Short Name
- PL7 IgG Ser Ql IA
- Display Name
- PL-7 IgG IA Ql (S)
- Consumer Name Alpha Get Info
- PL-7 IgG antibody, Blood
Example Answer List: LL2010-8
Source: Estonian Society of Laboratory Medicine| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| Borderline | LA4259-3 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.58
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Pl-7 IgG: |
| es-MX | Spanish (Mexico) | PL-7 Ab.IgG: |
| et-EE | Estonian (Estonia) | PL-7 antikehad.IgG: Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | Pl-7, IgG: |
| fr-FR | French (France) | PL-7 anticorps IgG: |
| fr-BE | French (Belgium) | Pl-7 Anticorps. IgG: Synonyms: Anticorps |
| it-IT | Italian (Italy) | PL-7 Ab.IgG: Synonyms: anticorpi IgG anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | PL-7 As.IgG: Synonyms: antistof; |
| ru-RU | Russian (Russian Federation) | PL-7 Ат.IgG: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | PL-7 Ab.IgG: Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut |
| zh-CN | Chinese (China) | Pl-7 抗体.IgG: Synonyms: Ab.IgG; |
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