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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP172674-6   Phospholipase A2 receptor Ab.IgG
The M-type phospholipase A2 receptor (PLA2R) stimulates the production of phospholipase A2 receptor autoantibodies. The PLA2R antibodies are a sensitive biomarker for idiopathic membranous nephropathy (MN). Over 80% of patients with MN are positive for PLA2R antibodies. MN is a syndrome where immune complexes deposit on the basement membrane and along with complement fixation alter the filtration barrier leading to proteinuria. The target antigens reside on the podocytes and is where the disease process begins. PLA2R antibodies are useful to diagnose and monitor treatment of MN. PMCID: PMC3103733 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Phospholipase A2 receptor Ab.IgG:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
Phospholipase A2 receptor IgG Ab [Presence] in Serum by Line blot
Short Name
PLA2R IgG Ser Ql Line blot
Display Name
Phospholipase A2 receptor IgG Line blot Ql (S)
Consumer Name Alpha Get Info
Phospholipase A2 Receptor IgG antibody, Blood

Part Model Get Info

  • Component
    Phospholipase A2 receptor Ab.IgG
    LP172674-6
    • Analyte
      Phospholipase A2 receptor Ab.IgG
      LP172674-6
      • Component Numerator
        Phospholipase A2 receptor Ab.IgG
        LP172674-6
        • Component Numerator Core
          Phospholipase A2 receptor
          LP172676-1
        • Component Numerator Core Suffix
          Ab.IgG
          LP32401-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG31602-2Phospholipase A2 receptor Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Fosfolipáza A2 receptor IgG:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
el-GRGreek (Greece)Υποδοχέας φωσφολιπάσης A2 Αντισώματα IgG:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: A2 Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γραμμή κηλίδωσης Ορός Υποδοχέας φωσφολιπάσης A2 Φωσφολιπάση
es-ESSpanish (Spain)Receptor fosfolipasa A2 IgG:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)Receptor de fosfolipasa A2 Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-FRFrench (France)Phospholipase A2 récepteur Ac IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)Fosfolipasi, recettore a2 Ab.IgG:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpi IgG anticorpo Presenza o Soglia Punto nel tempo (episodio) Recettore della fosfolipasi A2 Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)fosfolipase A2-receptor As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Receptor fosfolipazy A2 Ab.IgG:granica wykrywalności:punkt w czasie:surowica:uporządkowany:line blot
Synonyms: IgG Przeciwciała do receptora fosfolipazy A2 przeciwciała IgG Przeciwciała IgG przeciw receptorowi fosfolipazy A2
zh-CNChinese (China)磷脂酶 A2 受体 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: A2 型 Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Phospholipase A2 receptor;PLA2R 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 磷酸脂酶 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82926-7