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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP230274-5   3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab.IgG
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170 Source: Regenstrief LOINC, PMID: 24797170

LOINC Names Get Info

Fully-Specified Name
3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Ab.IgG:PrThr:Pt:Ser/Plas:Ord:Line blot
Long Common Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase IgG Ab [Presence] in Serum or Plasma by Line blot
Short Name
HMGCR IgG SerPl Ql Line blot
Display Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase IgG Line blot Ql
Consumer Name Alpha Get Info
3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase IgG antibody, Blood

Part Model Get Info

  • Component
    3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab.IgG
    LP230274-5
    • Analyte
      3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab.IgG
      LP230274-5
      • Component Numerator
        3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab.IgG
        LP230274-5
        • Component Numerator Core
          3-Hydroxy-3-Methylglutaryl-coenzyme A reductase
          LP220364-6
        • Component Numerator Core Suffix
          Ab.IgG
          LP32401-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both
Common Test Rank Get Info
17803

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)3-hydroxy-3-methylglutaryl-koenzym A reduktáza IgG:Přítomnost nebo práh:Časový bod:Sérum/plazma:Ordinální:Line blot
el-GRGreek (Greece)Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Αντισώματα IgG:PrThr:Pt:Ορός/Πλάσμα:Ord:Γραμμή κηλίδωσης
Synonyms: A Ord PrThr Pt SERO Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γραμμή κηλίδωσης Ορός Ορός/Πλάσμα Πλάσμα
es-ESSpanish (Spain)3-Hidroxy-3-metilglutaril-CoA reductasa IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot
es-MXSpanish (Mexico)3-hidroxi-3-metilglutaril-coenzima A reductasa Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha de línea
fr-FRFrench (France)3-hydroxy-3-méthyglutaryl-coenzyme A réductase Ac IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
it-ITItalian (Italy)3-idrossi-3-metilglutaril-coenzima A reduttasi Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Line blot
Synonyms: anticorpi IgG anticorpo Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)3-hydroxy-3-methylglutaryl-CoA-reductase As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Reduktaza 3-hydroksy-3-metyloglutarylo-koenzymu A Ab.IgG:granica wykrywalności:punkt w czasie:surowica lub osocze:uporządkowany:line blot
Synonyms: IgG przeciwciała IgG Przeciwciała IgG do reduktazy 3-hydroksy-3-metyloglutarylokoenzymu A Reduktaza HMG-CoA
zh-CNChinese (China)3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶;3-羟基-3-甲基戊二酰基辅酶 A 还原酶;3-羟基-3-甲基戊二酰辅酶 A 还原酶;3-羟基-3-甲基戊二酰-CoA 还原酶;3-羟基-3-甲基戊二酰基-CoA 还原酶;3-羟基-3-甲基戊二酰基 CoA 还原酶;3-羟基-3-甲基戊二酰 CoA 还原酶 Ⅲ A 型 Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Hydroxy III OH 三 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 叁 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 羟 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

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