Version 2.73

82990-33-Hydroxy-3-Methylglutaryl-coenzyme A reductase IgG Ab [Presence] in Serum or Plasma by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP230274-5   3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab.IgG
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. [PMID:24797170] Source: Regenstrief LOINC, PMID: 24797170

Fully-Specified Name

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Ab.IgG
Line blot

Additional Names

Short Name
HMGCR IgG SerPl Ql Line blot
Display Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase IgG Line blot Ql
Consumer Name Alpha
3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase IgG antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.73
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Common US Lab Results Rank

Language Variants Get Info

zh-CNChinese (China)
3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
nl-NLDutch (Netherlands)
3-hydroxy-3-methylglutaryl-CoA-reductase As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
fr-FRFrench (France)
3-hydroxy-3-méthylglutaryl-coenzyme A réductase anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
it-ITItalian (Italy)
3-idrossi-3-metilglutaril-coenzima A reduttasi Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Line blot
es-MXSpanish (Mexico)
3-hidroxi-3-metilglutaril-coenzima A reductasa Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha de línea
es-ESSpanish (Spain)
3-Hidroxy-3-metilglutaril-CoA reductasa IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info