82993-7

Mj IgG Ab [Presence] in Serum by Line blot

Active

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP230276-0   Mj Ab.IgG
Anti-Mj autoantibodies have been associated with adult polymyositis (PM) and dermatomyositis (DM), as well as juvenile dermatomyositis (JDM). The target of anti-Mj antibodies has been identified as NXP-2, also known as MORC3, a nuclear protein that has many functions including RNA metabolism and the maintenance of nuclear structure. Anti-Mj positive JDM has been associated with significant muscle weakness, polyarthritis, joint contractures, and intestinal vasculitis. Anti-Mj positive adult-onset DM is associated with calcinosis and a good response to therapy. PMID: 22546500 Source: Regenstrief LOINC, PMID: 22546500

LOINC Names Get Info

Fully-Specified Name

MJ Ab.IgG:PrThr:Pt:Ser:Ord:Line blot

Long Common Name

Mj IgG Ab [Presence] in Serum by Line blot

Short Name

Mj IgG Ser Ql Line blot

Display Name

Mj IgG Line blot Ql (S)

Consumer Name Alpha Get Info

Mj IgG antibody, Blood

Part Model Get Info

• Component

  Mj Ab.IgG
  LP230276-0

  • Analyte

    Mj Ab.IgG
    LP230276-0

    • Component Numerator

      Mj Ab.IgG
      LP230276-0

      • Component Numerator Core

        Mj
        LP220361-2

      • Component Numerator Core Suffix

        Ab.IgG
        LP32401-9

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  PrThr
  LP217195-9

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Ser
  LP7567-3

  • System Core

    Ser
    LP7567-3

  • Super System

    NULL
     

• Scale

  Ord
  LP7751-3

• Method

  Line blot
  LP266806-1

Example Answer List: LL360-9

Basic Attributes

Class

SERO

Type

Laboratory

First Released

Version 2.58

Last Updated

Version 2.64 (MAJ)

Change Reason

Mj changed to MJ to reflect the standard terminology.; This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.

Order vs. Observation

Both

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• Dermatomyositis, Adult Type
• Dermatomyositis, Childhood Type
• Immune globulin G
• Immunoglobulin G
• JDM
• MORC3
• NXP-2
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Serology
• Serum
• SR

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82993-7

Third Party Copyright

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.