Version 2.78

Part Description

LP221212-6   Cells.programmed cell death ligand 1
Programmed cell death-ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is the major ligand for the programmed cell death-1 (PD-1) receptor, which is present on the surface of T, B and NK cells and is part of the B7-CD28 superfamily. Binding PD-L1 and PD-L2 to the PD-1 receptor found on T-cells inhibits T cell proliferation and cytokine production. An increase PD-L1 expression occurs in some tumors, which helps protect them against active T-cell immune surveillance by binding to PD-1 and inhibiting the T-cell response. Positive PD-L1 immunohistochemistry in tumor cells may predict tumor response to therapy with immune checkpoint inhibitors, which are a new class of drugs that trigger an immune response against cancer cells by effectively suppressing the tumor's ability to inhibit the immune response. PMID: 25682184 Drugs in this class include pembrolizumab and nivolumab, both of which are anti-PD-1 receptor antibodies, and atezolizumab, which is an anti-PD-L1 antibody. PD-L1 may be a prognostic, diagnostic, and therapeutic marker in a variety of neoplasms, including carcinomas of the bladder, lung, and kidney. Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.programmed cell death ligand 1/100 viable tumor cells
Property
NFr
Time
Pt
System
Tiss
Scale
Qn
Method
Immune stain

Additional Names

Short Name
Cells.PD-L1/100 viab tum NFr Tiss ImStn
Display Name
Cells.programmed cell death ligand 1/100 viable tumor cells Immune stain (Tiss)
Consumer Name Alpha Get Info
Cells.programmed cell death ligand 1 per 100 Viable Tumor Cells, Tissue

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Observation
Common Test Rank Get Info
16229

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Células. Muerte celular programada del ligando 1/100 células tumorales viables:Fracción numérica:Punto temporal:Tejido:Qn:Tinción de inmunohistoquímica
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Células ligando de muerte celular programada 1/100 células tumorales viables:Fracción numérica:Punto temporal:Tejido y frotis:Cuantitativo:Mancha inmune
it-IT Italian (Italy) Cellule.ligando 1 di morte cellulare programmata/100 cellule tumorali vitali:NFr:Pt:Tessuto:Qn:Colorazione immunologica
Synonyms: Frazione numerica Patologia PD-L1 Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) cellen.geprogrammeerde celdood ligand 1/100 levensvatbare tumorcellen:getalsfractie:moment:weefsel en uitstrijkjes:kwantitatief:immunokleuring
pl-PL Polish (Poland) Komórki.ligand 1 programowanej śmierci komórki/100 żywych komórek nowotworowych:frakcja liczbowa:punkt w czasie:tkanka i rozmazy:ilościowy:barwnik immunologiczny
Synonyms: barwnik immunologiczny Ligand 1 programowanej śmierci komórki/100 żywych komórek nowotworowych Ligand receptora programowanej śmierci 1
zh-CN Chinese (China) 细胞.程序性死亡配体 1/100 个活肿瘤细胞:计数型分数:时间点:组织与涂片:定量型:免疫染色法
Synonyms: 100 个活（活的、存活、活性、可以存活的、有活力的）肿瘤细胞 Ⅰ I 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 细胞.程序性死亡配体-1;细胞.PD-L1 细胞含量;细胞性;细胞性质;细胞构成;细胞类

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83053-9