LOINC
Version 2.73

83069-5Zika virus non-structural protein 1 IgG Ab [Units/volume] in Serum or Plasma by ImmunoassayActive

Term Description

Quantitative analysis of Zika virus (ZIKV) non-structural protein 1 (NS1) IgG antibodies in serum or plasma specimens by immunoassay. The assay's use of the Zika NS1 antigen allows discrimination of ZIKV infections from other flavivirus infections, including dengue and chikungunya, which cause similar symptoms and are endemic in the same regions. This term was created for, but is not limited in use to, the submitter's Euroimmun Anti-Zika ELISA (IgG) test kit.
Source: Regenstrief LOINC

Part Description

LP221384-3   Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. [PMID:27417494]
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. [PMID:27148186]
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws. Source: Regenstrief LOINC, PMID: 27417494

Fully-Specified Name

Component
Zika virus non-structural protein 1 Ab.IgG
Property
ACnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Short Name
ZIKV NS1 IgG SerPl IA-aCnc
Display Name
ZIKV non-structural protein 1 IgG IA Qn
Consumer Name Alpha
Zika virus non-structural protein 1 IgG antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Member of these Groups

LG32774-8 Zika virus

Language Variants Get Info

zh-CNChinese (China)
寨卡病毒非结构蛋白 1 抗体.IgG:任意型浓度:时间点:血清/血浆:定量型:免疫测定法
nl-NLDutch (Netherlands)
zikavirus niet-structureel proteïne 1 As.IgG:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay
fr-FRFrench (France)
Zika virus protéine non structurelle 1 Ac IgG:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
de-DEGerman (Germany)
Zika-Virus Nichtstrukturprotein 1 Ak.IgG:Arbiträre Konzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Immunoassay
it-ITItalian (Italy)
Zika virus, proteina non strutturale 1 Ab.IgG:ACnc:Pt:Siero/Plasma:Qn:IA
es-MXSpanish (Mexico)
Proteína 1 Ab.IgG no estructural del virus del Zika:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
es-ESSpanish (Spain)
Proteína no estructural del virus del Zica IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA

Example Units

Unit Source
{EIA_index} Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83069-5