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Term Description

The percent of cells in bone marrow containing the 5q31 deletion involving the EGR1 gene can be detected by FISH and used for the diagnosis of chronic lymphocytic leukemia (CLL), multiple myeloma as well as other forms of cancer. This term is used to report the number of cells that have the deletion out of total number of cells examined (e.g. 80 out of 100 cells, or 80%). Results are also typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format LOINC 62356-1. This term is based, but not limited in use to, the Vysis LSI EGR1 (5q31) probe, which targets the EGR1 gene and flanking regions.

Part Description

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name
Cells.chromosome region 5q31 deletion/Cells counted:NFr:Pt:Bone mar:Qn:FISH
Long Common Name
Cells.chromosome region 5q31 deletion/Cells counted in Bone marrow by FISH
Short Name
Cells.5q31 Del/Cells NFr Mar FISH
Display Name
Cells.chromosome region 5q31 del/Cells counted FISH (BM)
Consumer Name Alpha Get Info
Cells.chromosome region 5q31/Cells Counted, Bone marrow

Part Model Get Info

  • Component
    Cells.chromosome region 5q31 deletion/Cells counted
    LP285644-3
    • Analyte
      Cells.chromosome region 5q31 deletion/Cells counted
      LP285644-3
      • Component Numerator
        Cells.chromosome region 5q31 deletion
        LP231915-2
        • Component Numerator Core
          Cells.chromosome region 5q31
          LP231914-5
        • Component Numerator Core Suffix
          deletion
          LP29253-9
      • Component Denominator
        Cells counted
        LP190810-4
        • Component Denominator Core
          Cells counted
          LP190810-4
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NFr
    LP6838-9
  • Time
    Pt
    LP6960-1
  • System
    Bone mar
    LP7410-6
    • System Core
      Bone mar
      LP7410-6
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    FISH
    LP62864-1

Basic Attributes

Class
MOLPATH.DELDUP
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.63 (MAJ)
Change Reason
Updated System from "Bone marrow" to "Bone mar" to be consistent with other laboratory bone marrow terms.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Buňky.chromozom oblast 5q31 delece/buňky spočítané:Početní podíl:Časový bod:Kostní dřeň:Kvantitativní:Fluorescenční in situ hybridizace (FISH)
el-GRGreek (Greece)Κύτταρα.χρωμοσωμική περιοχή 5q31 διαγραφή/Μετρηθέντα κύτταρα:NFr:Pt:Μυελός των οστών:Qn:Φθορίζουσα υβριδοποίηση in situ
Synonyms: MOLPATH MOLPATH.DELDUP NFr Pt Qn διαγραφή Κύτταρα Κύτταρα.χρωμοσωμική περιοχή 5q31 Μετρηθέντα κύτταρα Μυελός των οστών Οστό Περιοχή Φθορίζουσα υβριδοποίηση in situ Χρωμόσωμα Χρωμοσωμική περιοχή
es-ESSpanish (Spain)Región cromosómica 5q31 Deleción/Contaje celular:Fracción numérica:Punto temporal:Médula ósea:Qn:Hibridación in situ fluoresente (FISH)
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Deleción 5q31 de la región del cromosoma de células / Células contadas:Fracción numérica:Punto temporal:Médula ósea:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FRFrench (France)Chromosome région 5q31 délétion/cellules comptées:Fraction de nombres:Ponctuel:Moelle osseuse:Numérique:FISH
it-ITItalian (Italy)Cellule.cromosoma regione 5q31 Delezione/Cellule contate:NFr:Pt:Mid oss:Qn:FISH
Synonyms: Delezione o duplicazione genica Frazione numerica Ibridazione in situ fluorescente (FISH) Midollo osseo Patologia molecolare Punto nel tempo (episodio)
nl-NLDutch (Netherlands)cellen.chromosoomgebied 5q31 deletie/getelde cellen:getalsfractie:moment:beenmerg:kwantitatief:FISH
pl-PLPolish (Poland)Komórki. region chromosomowy 5q31 delecja/zliczone komórki:frakcja liczbowa:punkt w czasie:szpik kostny:ilościowy:FISH
Synonyms: fluorescencyjna hybrydyzacja in situ Komórki z delecją regionu 31 na długim ramieniu chromosomu 5 Komórki z delecją regionu 31 na długim ramieniu chromosomu 5 w stosunku do zliczonych komórek Komórki z obecnym regionem 11 na długim ramieniu chromosomu 5
zh-CNChinese (China)细胞.染色体区域 5q31 缺失/已计数的细胞:计数型分数:时间点:骨髓:定量型:FISH
Synonyms: Fluorescent in situ hybridization;荧光原位杂交 分子病理学;分子病理学试验 区;地区;局部 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 所计数的细胞;计数细胞;所计数细胞;已计数细胞 所计数细胞;已计数过细胞;已计数细胞;已计过数细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 染色体二体型+染色体三体型 染色体缺失;染色体区带缺失;基因缺失;缺损;基因缺损;基因删除;删除;基因丢失 染色体部位;染色体区;染色体区带;染色体部;染色体区域（染色体部位、染色体区、染色体区带、染色体部） 细胞.染色体区域（染色体部位、染色体区、染色体区带、染色体部） 5q31 细胞含量;细胞性;细胞性质;细胞构成;细胞类 骨骼;骨头 髓

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=84912-5