Log In

Part Description

LP220337-2   Nuclear Ab.IgG pattern.centrosomal
There are many nuclear staining patterns seen on HEp-2 cells: homogeneous, speckled, nucleolar, nuclear membranous, centromeric, nuclear dot and pleomorphic. The homogeneous pattern is seen when the condensed chromosomes and interphase chromatin stain and is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. Most antibodies are IgG, but IgM and IgA have also been detected. PMID: 19897433 There are two speckled patterns: fine and coarse. The fine speckled pattern has fine nuclear staining with unstained metaphase chromatin, which is associated with anti-Ro and anti-La antibodies. The coarse staining pattern has coarse granular nuclear staining, caused by anti-U1-RNP and anti-Sm antibodies. The nucleolar staining pattern is associated with many antibodies including anti-Scl-70, anti-PM-Scl, anti-fibrillarin and anti-Th/To. Nuclear membrane staining appears as a fluorescent ring around the cell nucleus and are produced by anti-gp210 and anti-p62 antibodies. The centromere pattern shows multiple nuclear dots in interphase and mitotic cells, corresponding to the number of chromosomes in the cell. Nuclear dot patterns show between 13-25 nuclear dots in interphase cells and are produced by anti-sp100 antibodies. Pleomorphic pattern is caused by antibodies to the proliferating cell nuclear antigen. PMID: 7604300 PMID: 11863229 PMID: 11303304 PMID: 19499499 Indirect immunofluorescence has been shown to be slightly superior compared to ELISA in detection of ANA from HEp-2 cells. PMID: 11430499 Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia

LOINC Names Get Info

Fully-Specified Name
Nuclear Ab.IgG pattern.centrosomal:Titr:Pt:Ser:SemiQn:IF
Long Common Name
Centrosomal nuclear IgG pattern [Titer] in Serum by Immunofluorescence
Short Name
ANA IgG centrosomal Titr Ser IF
Display Name
Centrosomal nuclear IgG pattern IF (S) [Titer]
Consumer Name Alpha Get Info
Centrosomal nuclear IgG pattern, Blood

Part Model Get Info

  • Component
    Nuclear Ab.IgG pattern.centrosomal
    LP220337-2
    • Analyte
      Nuclear Ab.IgG pattern.centrosomal
      LP220337-2
      • Component Numerator
        Nuclear Ab.IgG pattern.centrosomal
        LP220337-2
        • Component Numerator Core
          Nuclear Ab.IgG pattern.centrosomal
          LP220337-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    IF
    LP6323-2

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.75 (MAJ)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Antinukleární protilátky IgG centrozomální profil:Arbitrární koncentrace (titr):Časový bod:Sérum:Semikvantitativní:Imunofluoresecence (IF)
el-GRGreek (Greece)Μοτίβο πυρηνικών αντισωμάτων IgG.κεντροσωμικό:Titr:Pt:Ορός:Ημιποσοτική:Ανοσοφθορισμός
Synonyms: Pt SERO Titr Ανοσοσφαιρίνη G Ανοσοφθορισμός Ημιποσοτική Μοτίβο πυρηνικών αντισωμάτων IgG.κεντροσωμικό Ορός Πυρηνικό
es-ESSpanish (Spain)Anticuerpo nuclear IgG patrón centromérico:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Inmunofluorescencia (IF)
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Patrón de Ab.IgG nuclear centrífugo:Título:Punto temporal:Suero:Cuantitativo:Inmunofluorescencia (IF)
fr-FRFrench (France)Noyau anticorps IgG aspect centrosome:Titre:Ponctuel:Sérum:Semi-Quantitatif:Immunofluorescence
it-ITItalian (Italy)Ab nucleari.profilo IgG.centrosomiali:Titr:Pt:Siero:SemiQn:IF
Synonyms: Immunofluorescenza (IF) Profilo IgG nucleari centrosomiali Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NLDutch (Netherlands)nucleaire As.IgG patroon.centrosomaal:titer:moment:serum:semikwantitatief:immunofluorescentie
Synonyms: IF
pl-PLPolish (Poland)Jądrowe Ab.IgG wzór.centromerowy:miano:punkt w czasie:surowica:półilościowy:immunofluorescencja
Synonyms: IgG Przeciwciała IgG do jądra komórkowego Przeciwciała przeciwjądrowe Wzór centromerowy przeciwciał przeciwjądrowych IgG
zh-CNChinese (China)细胞核抗体.IgG 模式.中心体:滴定度:时间点:血清:半定量型:免疫荧光法
Synonyms: ANA FANA IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 NA 免疫球蛋白 G 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 核;胞核 核心抗体IgG 核心抗原抗体.IgG 核心抗原抗体IgG 核心抗原抗体免疫荧光 核抗体.IgG 核抗体IgG 核抗原抗体.IgG 核抗原抗体IgG 细胞核 Ab 细胞核 Ab.IgG 细胞核 IgG 细胞核抗体（ANA、抗核 Ab、抗核抗体、细胞核 Ab、胞核 Ab、胞核抗体）.IgG 模式.中心体 胞核 Ab 胞核 Ab.IgG 胞核抗体 胞核抗体.IgG 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

UnitSource
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85085-9