85095-8
D-3-phosphoglycerate dehydrogenase IgG Ab [Presence] in Serum by Line blot
Active
Term Description
The qualitative result for the detection of IgG antibodies to D-3-phosphoglycerate dehydrogenase (PGDH) antigens in serum or plasma for the diagnosis of autoimmune liver diseases, including autoimmune hepatitis and primary biliary cirrhosis. This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot).
Source: Regenstrief LOINC
Part Description
LP200136-2 D-3-phosphoglycerate dehydrogenase
D-3-phosphoglycerate dehydrogenase (3-PGDH) is encoded by the PHGDH gene, located on chromosome 1p12, and functions as part of the L-serine biosynthesis pathway to catalyze the conversion of 3-phospho-D-glycerate to 3-phosphohydroxypyruvate. Defects in the PHGDH gene are associated with two disorders: phosphoglycerate dehydrogenase(PGDH) deficiency and Neu-Laxova syndrome 1 (NLS1). PGDH deficiency is associated with congenital microcephaly, psychomotor retardation, and seizures. NLS1 is a lethal, autosomal recessive syndrome associated with ichthyosis, marked intrauterine growth restriction, microcephaly, hypoplastic lungs and central nervous system anomalies. [UniProt: O43175] Antibodies to 3-PGDH are detected in patients with chronic liver diseases, primiarily autoimmune hepatitis (AIH). PMID: 21707887
Source: Regenstrief LOINC, UniProt: O43175
Fully-Specified Name
- Component
- D-3-phosphoglycerate dehydrogenase Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- 3-PGDH IgG Ser Ql Line blot
- Display Name
- D-3-phosphoglycerate dehydrogenase IgG Line blot Ql (S)
- Consumer Name Alpha Get Info
- D-3-phosphoglycerate dehydrogenase IgG antibody, Blood
Preferred Answer List: LL2206-2
Source: Estonian Society of Laboratory Medicine| Answer | Code | Score | Answer ID |
|---|---|---|---|
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| Borderline | LA4259-3 | ||
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Strong positive | LA18996-1 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.67
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 85092-5 | Liver diseases autoimmune IgG panel - Serum or Plasma by Line blot |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | D-3-fosfoglicerato deshidrogenasa IgG: |
| es-MX | Spanish (Mexico) | D-3-fosfoglicerato deshidrogenasa IgG: |
| fr-FR | French (France) | 3-PGDH anticorps IgG: |
| it-IT | Italian (Italy) | D-3-deidrogenasi fosfoglicerato Ab.IgG: Synonyms: anticorpi IgG anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | D-3-fosfoglyceraat-dehydrogenase As.IgG: Synonyms: antistof; |
| zh-CN | Chinese (China) | D-3-磷酸甘油酸脱氢酶 抗体.IgG: Synonyms: Ⅲ Ab.IgG; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=85095-8
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright