85095-8

D-3-phosphoglycerate dehydrogenase IgG Ab [Presence] in Serum by Line blot

Active

Term Description

The qualitative result for the detection of IgG antibodies to D-3-phosphoglycerate dehydrogenase (PGDH) antigens in serum or plasma for the diagnosis of autoimmune liver diseases, including autoimmune hepatitis and primary biliary cirrhosis. This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot).

Part Description

LP200136-2 D-3-phosphoglycerate dehydrogenase
D-3-phosphoglycerate dehydrogenase (3-PGDH) is encoded by the PHGDH gene, located on chromosome 1p12, and functions as part of the L-serine biosynthesis pathway to catalyze the conversion of 3-phospho-D-glycerate to 3-phosphohydroxypyruvate. Defects in the PHGDH gene are associated with two disorders: phosphoglycerate dehydrogenase(PGDH) deficiency and Neu-Laxova syndrome 1 (NLS1). PGDH deficiency is associated with congenital microcephaly, psychomotor retardation, and seizures. NLS1 is a lethal, autosomal recessive syndrome associated with ichthyosis, marked intrauterine growth restriction, microcephaly, hypoplastic lungs and central nervous system anomalies. [UniProt: O43175] Antibodies to 3-PGDH are detected in patients with chronic liver diseases, primiarily autoimmune hepatitis (AIH). PMID: 21707887 Source: Regenstrief LOINC, UniProt: O43175

LOINC Names Get Info

Fully-Specified Name: D-3-phosphoglycerate dehydrogenase Ab.IgG:PrThr:Pt:Ser:Ord:Line blot
Long Common Name: D-3-phosphoglycerate dehydrogenase IgG Ab [Presence] in Serum by Line blot
Short Name: 3-PGDH IgG Ser Ql Line blot
Display Name: D-3-phosphoglycerate dehydrogenase IgG Line blot Ql (S)
Consumer Name Alpha Get Info: D-3-phosphoglycerate dehydrogenase IgG antibody, Blood

Part Model Get Info

Component
D-3-phosphoglycerate dehydrogenase Ab.IgG
LP231888-1
- Analyte
  D-3-phosphoglycerate dehydrogenase Ab.IgG
  LP231888-1
  - Component Numerator
    D-3-phosphoglycerate dehydrogenase Ab.IgG
    LP231888-1
    - Component Numerator Core
      D-3-phosphoglycerate dehydrogenase
      LP200136-2
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Line blot
LP266806-1

Preferred Answer List: LL2206-2

Source: Estonian Society of Laboratory Medicine

Answer	Code	Score	Answer ID
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
Borderline			LA4259-3
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Strong positive			LA18996-1

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.67 (MIN)
Change Reason: This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
85092-5	Liver diseases autoimmune IgG panel - Serum or Plasma by Line blot

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	D-3-fosfoglycerátdehydrogenáza IgG:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
el-GR	Greek (Greece)	D-3-φωσφογλυκερική αφυδρογονάση Αντισώματα IgG:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης Synonyms: D D-3-φωσφογλυκερική αφυδρογονάση Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γραμμή κηλίδωσης Ορός
es-ES	Spanish (Spain)	D-3-fosfoglicerato deshidrogenasa IgG:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	D-3-fosfoglicerato deshidrogenasa IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-FR	French (France)	D-3-phosphoglycérate déshydrogénase Ac IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT	Italian (Italy)	D-3-deidrogenasi fosfoglicerato Ab.IgG:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpi IgG anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	D-3-fosfoglyceraat-dehydrogenase As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Dehydrogenaza D-3-fosfoglicerynianowa Ab.IgG:granica wykrywalności:punkt w czasie:surowica:uporządkowany:line blot Synonyms: IgG Przeciwciała do dehydrogenazy D-3-fosfoglicerynianowej przeciwciała IgG Przeciwciała IgG do dehydrogenazy D-3-fosfoglicerynianowej
zh-CN	Chinese (China)	D-3-磷酸甘油酸脱氢酶抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: Ⅲ Ab.IgG;IgG;抗体 IgG Ab;自身抗体 III Rh;Rhesus;恒河猴;猕猴;罗猴三依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫球蛋白 G 去氢酶叁存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.