Version 2.78

Term Description

Dried blood spot (DBS) specimens have been used for therapeutic drug monitoring (TDM) across several classes of drugs including antimicrobials, anticonvulsants and immunosuppressants. DBS specimens are useful for TDM in infants and children due to the small sample volume required. DBS specimens are also useful for outpatient TDM in adults who have been trained to collect their own DBS because most analytes are relatively stable in DBS and the DBS card does not require specialized transportation. PMID: 25204403
Source: Regenstrief LOINC

Part Description

LP231897-2   Nitisinone
Nitisinone (brand name Orfadin) is a hydroxyphenyl-pyruvate dioxygenase inhibitor indicated as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 (HT-1). Patients with undiagnosed HT-1 usually present with liver failure. Nitisinone is used to prevent liver failure and treat those with those with chronic liver disease. Nitisinone is well tolerated and has few adverse effects. PMID: 16706549 Source: Regenstrief LOINC

Fully-Specified Name

Component
Nitisinone
Property
SCnc
Time
Pt
System
Bld.dot
Scale
Qn
Method
LC/MS/MS

Additional Names

Short Name
NTBC DBS LC/MS/MS-sCnc
Display Name
Nitisinone LC/MS/MS (DBS) [Moles/Vol]
Consumer Name Alpha Get Info
Nitisinone, Dried blood spot

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.61
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
94573-3 Tyrosinemia newborn screening follow-up and therapeutic monitoring panel - DBS

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Nitisinona:Concentración de sustancia:Punto temporal:gota de sangre (papel de filtro):Qn:LC/MS/MS
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Nitisinona:Concentración de sustancias:Punto temporal:DBS:Cuantitativo:LC / MS / MS
fr-FR French (France) Nitisinone:Moles/Volume:Ponctuel:Sang buvard:Numérique:LC/MS/MS
it-IT Italian (Italy) Nitisinone:SCnc:Pt:Sangue.su carta da filtro:Qn:LC/MS/MS
Synonyms: Concentrazione di Sostanza Livelli farmacologici e tossicologia NTBC Punto nel tempo (episodio) Sangue Spot sangue secco
nl-NL Dutch (Netherlands) nitisinon:mol/volume:moment:gedroogde bloedspot:kwantitatief:LC/MS/MS
zh-CN Chinese (China) 尼替西农:物质的量浓度:时间点:全血.斑点:定量型:LC/MS/MS
Synonyms: C14H10F3NO5;CAS 104206-65-7;2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione;Orfadin Tandem Mass Spectrometry;MS/MS;串联质谱分析;串联质谱法;mass spectrometer;MS;质谱法;质谱分析;liquid chromatography;LC;液相色谱分析;Liquid Chromatography-Tandem Mass Spectrometry;liquid chromatography-MS/MS;LC-MS/MS;液相色谱分析-串联质谱分析法;液相色谱-串联质谱检测方法;液相色谱质谱联用技术;串联质谱快速分析 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 全血斑点(滤纸);滤纸;血液.斑点;血液斑点(滤纸) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血;血液

Example Units

Unit Source
umol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85098-2