Version 2.78

Part Description

LP247790-1   Neutrophil.fMLP stimulated.DHR mean fluorescence intensity
Neutrophils are white blood cells that are critical to the healthy function of the immune system. They are drawn to sites of infection and injury to phagocytose and digest microbes. PMID: 22224774 Neutrophils rely on their ability to generate an oxidative burst to effectively kill microorganisms. The oxidative burst is a series of reactions involving NADPH oxidase that is triggered by receptors when they encounter bacterial peptides such as N-formyl-Met-Leu-Phe (fMLP) and phorbol myristate acetate (PMA) and which results in the production of superoxide anions and reactive oxygen species (ROS). PMID: 22262438 PMID: 10733101 The inability of neutrophils to create an oxidative burst can lead to a decreased ability to fight infection. Chronic granulomatous disease (CGD) is an x-linked or autosomal-recessive disorder where NADPH oxidase is improperly assembled which leads to an inadequate oxidative burst response and increased susceptibility to bacterial and fungal infections. PMID: 22262438 One method of assessing neutrophil function uses flow cytometry to measure the fluorescence of neutrophils that have been stimulated in the presence of the nonfluorescent dye dihydrorhodamine 123 (DHR 123), which, when oxidized, produces the fluorescent compound rhodamine 123. Both the percent of neutrophils having a burst response and the efficacy of that response as reflected by the mean fluorescence intensity (MFI) is measured. Depending on the underlying genetic cause and severity of CGD, some patients have a population of neutrophils that can generate a burst response but with lower MFI compared to healthy controls, while others only have neutrophils that are not capable of generating a response at all. PMID: 26912782 Source: Regenstrief LOINC

Fully-Specified Name

Component
Neutrophil.fMLP stimulated.DHR mean fluorescence intensity
Property
Arb
Time
Pt
System
Bld^Control
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
Neut.fMLP stim.DHR MFI Cont Bld FC
Display Name
Neutrophil.fMLP stim.DHR MFI FC (Bld control) [Units]
Consumer Name Alpha Get Info
Neutrophil.fMLP Stim.DHR MFI, control Blood

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.61
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
98122-5 Neutrophil.fMLP and PMA stimulated DHR panel by Flow cytometry (FC)
98123-3 Neutrophil.fMLP stimulated DHR panel by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Neutrofilos.Estimulados con fMLP.Intensidad media fluorescente con DHR:Arbitrario:Punto temporal:Sangre^control:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Neutrophil.fMLP estimulado.DHR intensidad de fluorescencia media:Arbitrario:Punto temporal:Sangre ^ Control:Cuantitativo:Citometría de flujo (FC)
fr-FR French (France) Polynucléaires neutrophiles stimulés par fLMP+DHR intensité de fluorescence:Arbitraire:Ponctuel:Sang du témoin:Numérique:Cytométrie de flux
it-IT Italian (Italy) Neutrofili.stimolati da fMLP.intensità media di fluorescenza DHR:Arb:Pt:Sangue^controllo:Qn:Citometria a flusso
Synonyms: Arbitrario Citometria a flusso (FC) Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) neutrofielen.fMLP gestimuleerd.DHR gemiddelde fluorescentie intensiteit:aanwezigheid:moment:bloed^controle:kwantitatief:flowcytometrie
pl-PL Polish (Poland) Neutrofil.stymulowany fMLP.DHR średnie natężenie fluorescencji:jednostka umowna:punkt w czasie:krew^kontrola:ilościowy:cytometria przepływowa (FC)
Synonyms: Neutrofil Neutrofile stymulowane fMLP, DHR średnie natężenie fluorescencji Odpowiedź neutrofilów po stymulacji na N-formylo-metionylo-leucylo-fenyloalaninę (fMLP), DHR
zh-CN Chinese (China) 嗜中性粒细胞.经 fMLP 刺激.DHR 平均荧光强度:任意型:时间点:全血^对照:定量型:流式细胞测量术
Synonyms: PMN;中性;中性白细胞;中性粒细胞;嗜中性;嗜中性白细胞;多形核;多形核白细胞;多形核粒细胞;多形核粒细胞（PMN） 任意;任意的;人工型 全血^对照 全血^对照物 动态 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 嗜中性粒细胞（中性、中性粒、中性粒细胞、嗜中性、Neu）.经 fMLP（N-formyl-Met-Leu-Phe、N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸） 刺激.DHR（二氢罗丹明、二氢罗丹明 123、dihydrorhodamine 123、DHR 123） 嗜中性粒细胞（中性、中性粒、中性粒细胞、嗜中性、Neu）.经 fMLP（N-formyl-Met-Leu-Phe、N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸） 刺激.DHR（二氢罗丹明、二氢罗丹明 123、dihydrorhodamine 123、DHR 123） 平均荧光强度（平均荧光亮度、mean fluorescence intensity、MFI） 对照品;正常;正常对照;正常对照品;超系统 - 对照 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 血;血液 血液^对照物 血液学/细胞计数;血液学与细胞计数

Example Units

Unit Source
[arb'U] Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85371-3