Version 2.78

Part Description

LP247787-7   Neutrophil.fMLP stimulated.DHR
Neutrophils are white blood cells that are critical to the healthy function of the immune system. They are drawn to sites of infection and injury to phagocytose and digest microbes. PMID: 22224774 Neutrophils rely on their ability to generate an oxidative burst to effectively kill microorganisms. The oxidative burst is a series of reactions involving NADPH oxidase that is triggered by receptors when they encounter bacterial peptides such as N-formyl-Met-Leu-Phe (fMLP) and phorbol myristate acetate (PMA) and which results in the production of superoxide anions and reactive oxygen species (ROS). PMID: 22262438 PMID: 10733101 The inability of neutrophils to create an oxidative burst can lead to a decreased ability to fight infection. Chronic granulomatous disease (CGD) is an x-linked or autosomal-recessive disorder where NADPH oxidase is improperly assembled which leads to an inadequate oxidative burst response and increased susceptibility to bacterial and fungal infections. PMID: 22262438 One method of assessing neutrophil function uses flow cytometry to measure the fluorescence of neutrophils that have been stimulated in the presence of the nonfluorescent dye dihydrorhodamine 123 (DHR 123), which, when oxidized, produces the fluorescent compound rhodamine 123. Both the percent of neutrophils having a burst response and the efficacy of that response as reflected by the mean fluorescence intensity (MFI) is measured. Depending on the underlying genetic cause and severity of CGD, some patients have a population of neutrophils that can generate a burst response but with lower MFI compared to healthy controls, while others only have neutrophils that are not capable of generating a response at all. PMID: 26912782 Source: Regenstrief LOINC

Fully-Specified Name

Component
Neutrophil.fMLP stimulated.DHR/Neutrophil.fMLP stimulated.total
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
Neut.fMLP DHR/Neut fMLP NFr Bld FC
Display Name
Neutrophil.fMLP stimulated.DHR/Neutrophil.fMLP stimulated.total FC (Bld)
Consumer Name Alpha Get Info
Neutrophil.fMLP Stimulated.DHR/Neutrophil.fMLP Stimulated.total, Blood

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.61
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
98122-5 Neutrophil.fMLP and PMA stimulated DHR panel by Flow cytometry (FC)
98123-3 Neutrophil.fMLP stimulated DHR panel by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Neutrofilos.Estimulación con fMLP.DHR (dihidrorodamina)/Neutrófilos fMLP estimulados totales:Fracción numérica:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Neutrophil.fMLP estimulado.DHR / Neutrophil.fMLP estimulado.total:Fracción numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
fr-FR French (France) Polynucléaires neutrophiles stimulés par fLMP+DHR/Polynucléaires neutrophiles fMLP stimulés totaux:Fraction de nombres:Ponctuel:Sang:Numérique:Cytométrie de flux
it-IT Italian (Italy) Neutrofili.stimolati da fMLP.DHR/Neutrofili.stimolati da fMLP.totale:NFr:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Citometria a flusso (FC) Ematologia (coagulazione) conta differenziale Frazione numerica Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) neutrofielen.fMLP gestimuleerd.DHR/neutrofielen.fMLP gestimuleerd.totaal:getalsfractie:moment:bloed:kwantitatief:flowcytometrie
pl-PL Polish (Poland) Neutrofil.stymulowany fMLP.DHR/neutrofile stymulowane N-formylometionylo-leucylo-fenyloalaniną:frakcja liczbowa:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: Neutrofil Neutrofile stymulowane fMLP.DHR/Neutrofile stymulowane fMLP łącznie Odpowiedź neutrofilów po stymulacji na N-formylo-metionylo-leucylo-fenyloalaninę (fMLP), DHR
zh-CN Chinese (China) 嗜中性粒细胞.经 fMLP 刺激.DHR/嗜中性粒细胞.经 fMLP 刺激.总计:计数型分数:时间点:全血:定量型:流式细胞测量术
Synonyms: PMN;中性;中性白细胞;中性粒细胞;嗜中性;嗜中性白细胞;多形核;多形核白细胞;多形核粒细胞;多形核粒细胞（PMN） 全体数量 全部 共计 动态 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 嗜中性粒细胞（中性、中性粒、中性粒细胞、嗜中性、Neu）.经 fMLP（N-formyl-Met-Leu-Phe、N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸） 刺激.DHR（二氢罗丹明、二氢罗丹明 123、dihydrorhodamine 123、DHR 123） 嗜中性粒细胞（中性、中性粒、中性粒细胞、嗜中性、Neu）.经 fMLP（N-formyl-Met-Leu-Phe、N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸） 刺激.总计（总和、总） 总 总和 总数 总量 总额 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 汇总 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 血;血液 血液学/细胞计数;血液学与细胞计数

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85373-9