85374-7
Neutrophil.PMA stimulated.DHR mean fluorescence instensity in Blood by Flow cytometry (FC)
Active
Part Description
LP247786-9 Neutrophil.PMA stimulated.DHR mean fluorescence intensity
Neutrophils are white blood cells that are critical to the healthy function of the immune system. They are drawn to sites of infection and injury to phagocytose and digest microbes. PMID: 22224774 Neutrophils rely on their ability to generate an oxidative burst to effectively kill microorganisms. The oxidative burst is a series of reactions involving NADPH oxidase that is triggered by receptors when they encounter bacterial peptides such as N-formyl-Met-Leu-Phe (fMLP) and phorbol myristate acetate (PMA) and which results in the production of superoxide anions and reactive oxygen species (ROS). PMID: 22262438 PMID: 10733101 The inability of neutrophils to create an oxidative burst can lead to a decreased ability to fight infection. Chronic granulomatous disease (CGD) is an x-linked or autosomal-recessive disorder where NADPH oxidase is improperly assembled which leads to an inadequate oxidative burst response and increased susceptibility to bacterial and fungal infections. PMID: 22262438 One method of assessing neutrophil function uses flow cytometry to measure the fluorescence of neutrophils that have been stimulated in the presence of the nonfluorescent dye dihydrorhodamine 123 (DHR 123), which, when oxidized, produces the fluorescent compound rhodamine 123. Both the percent of neutrophils having a burst response and the efficacy of that response as reflected by the mean fluorescence intensity (MFI) is measured. Depending on the underlying genetic cause and severity of CGD, some patients have a population of neutrophils that can generate a burst response but with lower MFI compared to healthy controls, while others only have neutrophils that are not capable of generating a response at all. PMID: 26912782
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Neutrophil.PMA stimulated.DHR mean fluorescence intensity
- Property
- Arb
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- Flow cytometry
Additional Names
- Short Name
- Neut.PMA stim.DHR MFI Bld FC
- Display Name
- Neutrophil.PMA stim.DHR MFI FC (Bld) [Units]
- Consumer Name Alpha Get Info
- Neutrophil.PMA Stim.DHR MFI, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 6661
Member of these Panels
LOINC | Long Common Name |
---|---|
98122-5 | Neutrophil.fMLP and PMA stimulated DHR panel by Flow cytometry (FC) |
98124-1 | Neutrophil.PMA stimulated DHR panel by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Neutrofilos. Estimulados con PMA. Intensidad media fluorecente DHR: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Neutrophil.PMA estimulado.DHR intensidad de fluorescencia media: |
fr-FR | French (France) | Polynucléaires neutrophiles stimulés par PMA+DHR intensité de fluorescence: |
it-IT | Italian (Italy) | Neutrofili.stimolati da PMA.intensità media di fluorescenza DHR: Synonyms: Arbitrario Citometria a flusso (FC) Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | neutrofielen.PMA gestimuleerd.DHR gemiddelde fluorescentie intensiteit: |
pl-PL | Polish (Poland) | Neutrofil.stymulowany PMA.DHR średnia natężenia fluorescencji: Synonyms: Neutrofil Neutrofile stymulowane PMA, DHR Neutrofile stymulowane PMA, DHR średnia natężenia fluorescencji |
uk-UA | Ukrainian (Ukraine) | Нейтрофіли.стимульований PMA.DHR середня інтенсивність флуоресценції: Synonyms: Arbitrary; |
zh-CN | Chinese (China) | 嗜中性粒细胞.经 PMA 刺激.DHR 平均荧光强度: Synonyms: PMN; |
Example Units
Unit | Source |
---|---|
[arb'U] | Example UCUM Units |
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