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Part Description

LP247810-7   Erythrocytes.EMA mean fluorescence intensity
Eosin-5-maleimide (EMA) is a fluorescent dye used in flow cytometry to screen for hereditary spherocytosis (HS). Patients with HS have red blood cells (RBC) that are overly rigid and misshapen and are removed by the spleen for destruction which leads to anemia, jaundice and splenomegaly. EMA binds covalently to Lys-430 on the first extracellular loop of the Band 3 protein on RBCs. The cytoplasmic portion of Band 3 communicates with ankyrin and protein 4.2 that are crosslinked with the spectrin-based cytoskeleton that acts to stabilize the cell membrane. When band 3 is deficient or abnormal on RBCs fluorescence using EMA may be reduced. The mean fluorescent intensity (MFI) of the patient and control cells is measured and the result is expressed as a ratio of patient MFI to control MFI.[Dacie and Lewis Practical Haematology, 11th edition, Barbara J. Bain, Imelda Bates, Mike A. Laffan, S. Mitchell Lewis, pp250-251]MedlinePlus Condition: hereditary-spherocytosis] Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Erythrocytes.EMA mean fluorescence intensity actual/normal:RelRto:Pt:Bld:Qn:Flow cytometry
Long Common Name
Erythrocytes.EMA mean fluorescence intensity actual/normal in Blood by Flow cytometry (FC)
Short Name
RBC.EMA MFI Act/Nor Bld FC
Display Name
RBC.EMA MFI actual/normal FC (Bld) [Relative ratio]
Consumer Name Alpha Get Info
Red Blood Cells EMA Mean Fluorescence Intensity actual/normal, Blood

Part Model Get Info

  • Component
    Erythrocytes.EMA mean fluorescence intensity actual/normal
    LP247806-5
    • Analyte
      Erythrocytes.EMA mean fluorescence intensity actual/normal
      LP247806-5
      • Component Numerator
        Erythrocytes.EMA mean fluorescence intensity actual/normal
        LP247806-5
        • Component Numerator Core
          Erythrocytes.EMA mean fluorescence intensity
          LP247810-7
        • Component Numerator Core Suffix
          actual/normal
          LP29333-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    RelRto
    LP6854-6
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Flow cytometry
    LP6274-7

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.61 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Erytrocyty.EMA střední intenzita fluorescence aktuální/normální:Relativní poměr:Časový bod:Krev:Kvantitativní:Průtoková cytometrie
el-GRGreek (Greece)Ερυθροκύτταρα.μέση ένταση φθορισμού EMA πραγματικό/φυσιολογικό:RelRto:Pt:Αίμα:Qn:Κυτταρομετρία ροής
Synonyms: HEM/BC Pt Qn RelRto Αίμα Ερυθροκύτταρα Ερυθροκύτταρα.μέση ένταση φθορισμού EMA Κυτταρομετρία ροής πραγματικό/φυσιολογικό
es-ESSpanish (Spain)Eritrocitos. Intensidad media de fluorescencia de EMA actual/normal:Ratio relativo:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Eritrocitos.EMA intensidad media de fluorescencia real / normal:Razón relativa:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
fr-FRFrench (France)Érythrocytes EMA intensité de fluorescence patient/témoin:Ratio relatif:Ponctuel:Sang:Numérique:Cytométrie de flux
it-ITItalian (Italy)Eritrociti.EMA significato dell'intensità della fluorescenza effettivo/normale:RelRto:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Citometria a flusso (FC) Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Rapporto Relativo Sangue
nl-NLDutch (Netherlands)erytrocyten.EMA gemiddelde fluorescentie intensiteit gemeten/normaal:relatieve verhouding:moment:bloed:kwantitatief:flowcytometrie
Synonyms: gemeten/normaal
pl-PLPolish (Poland)Erytrocyty, średnia intensywność fluorescencji EMA badane/prawidłowe:współczynnik względny:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: Erytrocyty o średniej intensywności fluorescencji EMA, badane Erytrocyty o średniej intensywności fluorescencji EMA, badane/prawidłowe
zh-CNChinese (China)红细胞.EMA 平均荧光强度 实际的/正常的:相对比率:时间点:全血:定量型:流式细胞测量术
Synonyms: RBC;RBCS;盘状细胞;红血球;红血细胞;血液制品 - 红细胞 动态 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 实测值 实测值/正常值;实际/正常;实际值/正常值;实际测定值/正常值 实测的 实际值 对照 对照标准 对照物 对照的 时刻;随机;随意;瞬间 来自于不同体系的两种分析物之比;相对比;相对比值 正常的 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 红细胞.EMA（Eosin-5-maleimide、伊红-5-马来酰亚胺、伊红-5-顺丁烯二酰亚胺） 平均荧光强度（平均荧光亮度、mean fluorescence intensity、MFI） 血;血液 血液学/细胞计数;血液学与细胞计数

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85378-8