85379-6
Purine/Pyrimidine [Ratio] in Red Blood Cells by Spectrophotometry
Active
Term Description
The purine to pyrimidine ratio is a marker of pyrimidine-5-nucleotidase (P5N) which is an enzyme in the cytoplasm of human red blood cells. The function
of P5N is unknown but a deficiency of the enzyme causes congenital haemolytic anemia. Individuals who are heterozygous for the recessive P5N gene
demonstrate no clinical or hematological abnormalities while those homozygous for the recessive P5N gene have a corresponding 5-30% reduction in
normal enzyme activity. P5N deficiency leads to chronic non-spherocytic haemolytic anaemia associated with mild to moderate hemolysis, increased
basophilic stippling in 5% of the red blood cells and an elevation of red cell glutathione and pyrimidine nucleotides. The diagnosis of P5N deficiency is
based on the change in the level of cytidine and uridine in red blood cells which is normally very low but increases to over 50% in P5N deficient patients.
Measurement of P5N is by light absorption at different wavelengths. In acidic solution pyrimidine nucleotides absorb the maximum amount of light at 280
nanometers (nm). Purine nucleotides absorb the maximum amount of light at 260 nm. The ratio of light absorbed at 260 nm to that at 280 nm in a pool of
red blood cells indicates the relative amount of purines to pyrimidines. The ratio is lower than normal when pyrimidine levels are increased.[PMID:
23992312][ Dacie and Lewis Practical Haematology, 11th edition, Barbara J. Bain, Imelda Bates, Mike A. Laffan, S. Mitchell Lewis, p259]
LOINC Names Get Info
- Fully-Specified Name
- Purine/pyrimidine:
Ratio: Pt: RBC: Qn: Spectrophotometry - Long Common Name
- Purine/Pyrimidine [Ratio] in Red Blood Cells by Spectrophotometry
- Short Name
- Purine/Pyrimidine RBC Spect-Rto
- Display Name
- Purine/Pyrimidine Spectrophotometry (RBC) [Ratio]
- Consumer Name Alpha Get Info
- Purine/Pyrimidine, Red blood cells
Part Model Get Info
- Component
- Purine/pyrimidine
LP286955-2
- Analyte
- Purine/pyrimidine
LP286955-2
- Component Numerator
- Purine
LP247699-4
- Component Numerator Core
- Purine
LP247699-4
- Component Numerator Core Suffix
- NULL
- Component Denominator
- Pyrimidine
LP247727-3
- Component Denominator Core
- Pyrimidine
LP247727-3
- Component Denominator Core Suffix
- NULL
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- Ratio
LP6852-0
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- RBC
LP7536-8
- System Core
- RBC
LP7536-8
- Super System
- NULL
- Scale
- Qn
LP7753-9
- Method
- Spectrophotometry
LP6525-2
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.61 (ADD)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Purin/pyrimidin: |
| el-GR | Greek (Greece) | Πουρίνη/Πυριμιδίνη: Synonyms: CHEM Pt Qn Ratio Ερυθρά αιμοσφαίρια Πουρίνη Πυριμιδίνη Φασματοφωτομετρία |
| es-ES | Spanish (Spain) | Purina/Pirimidina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Purina / pirimidina: |
| fr-FR | French (France) | Purine/pyrimidine: |
| it-IT | Italian (Italy) | Purina/Pirimidina: Synonyms: Chimica Globuli rossi Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | purine/pyrimidine: Synonyms: rode bloedcellen |
| zh-CN | Chinese (China) | 嘌呤/嘧啶: Synonyms: RBC; |
Example Units
| Unit | Source |
|---|---|
| {ratio} | Example UCUM Units |
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