85496-8

Streptococcus pneumoniae serotype [Identifier] in Specimen by NAA with probe detection

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Term Description

Due to serotype-specific vaccines, serotyping of the streptococcus pneumoniae is required to monitor the epidemiology of infections, as some serotypes cause more virulent disease than others.[PMCID: 3405617]
Source: Regenstrief LOINC

Part Descriptions

LP14410-2   Streptococcus pneumoniae
Streptococcus pneumoniae are gram-positive cocci that are nonmotile and nonsporulating and usually require complex culture media. Older streptococcal cultures, beyond the most active growth period (the logarithmic phase), sometimes lose their gram-positive staining characteristics. S. pneumoniae are part of the normal respiratory tract flora. Disease usually results due to the acquisition of a new strain following a change in the normal flora, often due to a preceding virus. S. pneumonaie causes otitis media, sinusitis and pneumonia in the middle ear, sinuses or lungs, respectively. Meningitis can occur by bloodstream invasion from the lungs or by extension of otitis media or sinusitis to the meninges. Bacteremia can result in osteomyelitis (infection of bones) or arthritis (of joints). Most bacterial pneumonia occurring after the neonatal period is caused by S. pneumoniae. Pneumococcal pneumonia is seen most commonly in elderly or immunosuppressed individuals. In the United States, it is most prevalent in winter. Diagnosis is usually based on a sputum Gram stain and culture although blood or cerebrospinal fluid may be cultured. While penicillin has been the standard treatment, some strains have proven resistant to penicillin and multiple antibiotics. A vaccine exists. [NCBI Books:NBK7611] Source: Regenstrief LOINC

LP253527-8   Streptococcus pneumoniae serotype
Streptococcus pneumoniae is an important human pathogen whose virulence is based primarily on its polysaccharide capsule, which protects it by shielding it from the immune system. Over time, study of the polysaccharide capsule has identified multiple serogroups and serotypes. Serotypes are defined based on the chemical structure and immunologic properties of the polysaccharide, and each serogroup contains one or more serotypes that elicit the same antibody response. Over time, two parallel serogroup and serotype naming systems arose, one in the U.S. and one in Denmark, but more recently, the Danish naming system is the one that has been widely adopted, including in the U.S. Beginning with the June 2017 release, LOINC adopted the Danish numbering system in the Component for all pneumococcal terms.
Out of more than 90 serotypes identified to date, only a third have been implicated in invasive disease, and there is also an association between specific serotypes, patient age, and mortality rate. For example, serotypes 1 and 5 are associated with invasive disease, and historically, serogroups 6, 14, 18, and 19 were more common among young children while serotype 3 was more common in the elderly. Vaccines have changed the prevalence of different serotypes and serogroups. Pneumococcal vaccines target the serotypes that are commonly implicated in human disease, and over time, the number of targeted serotypes have increased from 7 to 23. While widespread vaccination has significantly decreased the incidence of invasive pneumococcal disease caused by the serotypes covered by those vaccines, it has also caused a change in serotype prevalence in that strains that were rare are becoming more common. Therefore, determining the specific serotype responsible for new cases is important for epidemiologic tracking and future vaccine development.
PMID: 26085553 Source: Regenstrief LOINC

Fully-Specified Name

Component

Streptococcus pneumoniae serotype

Property

Prid

Time

Pt

System

XXX

Scale

Nom

Method

Probe.amp.tar

Additional Names

Short Name

S pneum Sertyp Spec NAA+probe

Display Name

S. pneumoniae serotype NAA+probe Nom (Specimen)

Consumer Name Alpha Get Info

Streptococcus pneumoniae serotype, Specimen

Example Answer List: LL4346-4

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.69

Order vs. Observation

Both

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• DNA NUCLEIC ACID PROBE
• DNA probe
• ID
• Identity or presence
• Infectious Disease
• InfectiousDisease
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Microbiology
• Misc
• Miscellaneous
• NAA+probe
• NAAT
• NASBA
• Nominal
• Nucleic acid sequence based analysis
• Other
• PCR
• Pneu
• pneum
• Pneumo
• Pneumococ
• Pneumococcal
• Pneumococcal pneumonia
• Pneumococcus
• Pneumon
• Pneumonia
• Point in time
• Polymerase chain reaction
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• Random
• S pneum serotype
• S pneumo
• S pneumoniae
• SDA
• Sertyp
• Spec
• Spn
• Strand Displacement Amplification
• Strep
• Strept
• TMA
• To be specified in another part of the message
• Transcription mediated amplification
• Unspecified

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