Version 2.80

Term Description

Neutralization methods such as fluorescent focus neutralization (FFN) is used to confirm positive Porcine Reproductive and Respiratory Syndrome (PRRS) results found with screening methods such as ELISA. It uses sample and control serums that are diluted and incubated on the PRRSV infected cells followed by florescent microscopic examination for characteristic patterns of fluorescent staining. Confirmatory tests are pivotal to provide a definitive diagnosis because false positives or negatives result in significant economic loss to livestock producers.

Part Descriptions

LP174536-5   Porcine reproductive and respiratory syndrome virus North American strain
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) causes an infection in pigs sometimes known as Blue-Ear Pig Disease. This economically important pandemic disease causes reproductive failure in breeding stock and respiratory tract illness and has shown differences in virulence, tissue trophism and replication capabilities among strains.
PRRSV has two genotypes - the North American strain (type 2 PRRSv, with the isolate prototype VR2332) and the European strain (type 1 PRRSv, with the isolate prototype "Lelystad"). Both types were discovered in their local regions around 1990 but they now share worldwide distributions. These two main genotypes differ genetically by approximately 40%. Within each genotype there is nucleotide divergence of up to 30% (Leung et al., 2010). The majority of the nucleotides that make up the two are the same but diversity within each genotype is high with a significant geographic pattern for the various types. The use of sequence information to compare PRRSV isolates is a valuable tool to monitor PRRSV strains both globally and within a farm over time. It can differentiate between resident and newly introduced viruses as well as between vaccine and field strains.
PMID: 12167339
[http://www.porcilis-prrs.com/prrs-infection.asp] Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

Fully-Specified Name

Component
Porcine reproductive and respiratory syndrome virus North American strain Ab.Neut
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method
Neut

Additional Names

Long Common Name
PRRSV North American strain neutralizing antibody [Titer] in Serum by Neutralization test
Short Name
PRRSV NA strain NAb Titr Ser Nt
Display Name
PRRSV North American strain neut ab Neut test (S) [Titer]
Consumer Name Alpha Get Info
PRRSV North american strain neutralizing antibody, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.75 (MAJ)
Change Reason
Abbreviated "Porcine reproductive and respiratory syndrome virus" to "PRRSV" in the Long Common Name. PRRSV is shorter and more commonly used in test names.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85551-0 PRRSV European and North American strains neutralizing antibody panel - Serum by Neutralization test

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Στέλεχος Βόρειας Αμερικής του ιού του αναπαραγωγικού και αναπνευστικού συνδρόμου των χοίρων Ab.Neut:Titr:Pt:Ορός:Ημιποσοτική:Ουδετερόφιλα
Synonyms: Titr Ιός Ιός του αναπαραγωγικού και αναπνευστικού συνδρόμου των χοίρων Στέλεχος Βόρειας Αμερικής του ιού του αναπαραγωγικού και αναπνευστικού συνδρόμου των χοίρων Των χοίρων
es-ES Spanish (Spain) Cepa norteamericana del virus del síndrome reproductivo y respiratorio porcino Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Virus del síndrome respiratorio y reproductivo porcino cepa norteamericana Ab.Neut:Título:Punto temporal:Suero:Cuantitativo:Prueba de neutralización
it-IT Italian (Italy) Virus della sindrome riproduttiva e respiratoria del suino, variante Nord Americana Ab.Neut:Titr:Pt:Siero:SemiQn:Neut
Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Siero Test di neutralizzazione Titolo Variante Nord Americana virus PRRS Virus PRRS
nl-NL Dutch (Netherlands) 'porcine' reproductief en respiratoir syndroomvirus Noord-Amerikaanse strain As.neutraliserend:titer:moment:serum:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam porcine voortplantings- en respiratoir syndroom virus van varken; PRRSV
zh-CN Chinese (China) 猪生殖与呼吸综合征病毒北美株 抗体.中和:滴定度:时间点:血清:半定量型:中和试验
Synonyms: Ab;自身抗体 Lelystad 病毒;PRRS;SIRSV;兰耳病;新猪病;母猪后期流产;猪不育和呼吸综合症;猪不育和呼吸综合症（Swine infertility and respiratory syndrome，SIRSV）;猪生殖与呼吸系统综合症;猪生殖与呼吸综合症（Porcine reproductive and respiratory syndrome，PRRS）;猪繁殖与呼吸综合征;猪蓝耳病;猪蓝色病;神秘仔猪病;神秘猪病;莱利斯塔猪病毒（Lelystad Virus，LV）;蓝耳猪病;蓝耳病;蓝色流产症 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 猪生殖与呼吸综合征病毒北美洲株;PRRSV;猪生殖呼吸综合征病毒;猪呼吸繁殖综合征病毒;猪繁殖与呼吸道综合征病毒;猪繁殖和呼吸障碍综合征;Porcine Reproductive and Respiratory Syndrome;PRRS;蓝耳病;Blue Ear Disease 猪的 猪科 猪科的

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85547-8