86565-9

Influenza virus A Ag [Presence] in Tissue by Immunofluorescence

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Part Description

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. PMID: 20542248 ] PMID: 25812763
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component

Influenza virus A Ag

Property

PrThr

Time

Pt

System

Tiss

Scale

Ord

Method

IF

Additional Names

Short Name

FLUAV Ag Tiss Ql IF

Display Name

FLUAV Ag IF Ql (Tiss)

Consumer Name Alpha Get Info

Influenza A (Flu A) antigen, Tissue

Example Answer List: LL1937-3

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.61

Order vs. Observation

Both

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ACIF
• Anticomplement Immunofluorescence
• Antigen
• Antigens
• Avian influenza
• Bird flu
• DFA
• FA
• FLUA
• FLUAV
• Fluorescent antibody
• Fluoresent
• FLUV
• Fowl plague
• ID
• IFA
• Immune fluorescence
• Immunoflour
• Immunofluor
• Immunofluorescence
• Infectious Disease
• InfectiousDisease
• Influ
• Influenza A
• Influenza A virus
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Time Resolved Fluorescence
• Tissue
• Tissue, unspecified
• TRF

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.