86607-9
Cocaine/Creatinine [Mass Ratio] in Urine by Confirmatory method
Active
Part Descriptions
LP16048-8 Cocaine
Cocaine is an alkaloid of Erythroxylon coca that is grown in the northern South American Andes, India, Africa and Java. It is used medicinally as a local anesthetic and vasoconstrictor in nasal surgery and to dilate pupils. Because cocaine is a powerful central nervous system stimulant it is among the most abused drugs. Cocaine abuse can lead to sudden death due to cardiotoxicity or the sequential development of hyperthermia, agitated delirium and respiratory arrest. Cocaine is metabolized in the liver to inactive benzoylecgonine (BZE). BZE is pharmacologically inactive and has a longer half-life than its parent drug cocaine. It is the substance most tested for when investigating suspected cocaine abuse. Cocaethylene (CE) is produced in the liver in the presence of ethanol and has been shown to have similar stimulatory effects as cocaine in animal studies.(Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, Seventh Edition) Cocaethylene is toxic to the myocardium. PMID: 8761012
Source: Regenstrief LOINC
LP16048-8 Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Source: National Library of Medicine, MeSH 2006
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- Cocaine/Creatinine
- Property
- MRto
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
- Confirm
Additional Names
- Short Name
- Cocaine/Creat Ur Cfm
- Display Name
- Cocaine/Creatinine Confirm (U) [Mass ratio]
- Consumer Name Alpha Get Info
- Cocaine/Creatinine, Urine
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 4868
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Cocaína/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Cocaína / Creatinina: |
| et-EE | Estonian (Estonia) | Kokaiin/kreatiniin: Synonyms: Juhuslik Kvantitatiivne Uriin |
| fr-CA | French (Canada) | Cocaïne/Créatinine: |
| fr-FR | French (France) | Cocaïne/créatinine: |
| fr-BE | French (Belgium) | Cocaïne/Créatinine: Synonyms: Rapport de masse |
| it-IT | Italian (Italy) | Cocaina/Creatinina: Synonyms: Livelli farmacologici e tossicologia Punto nel tempo (episodio) Rapporto di Massa |
| nl-NL | Dutch (Netherlands) | cocaïne/creatinine: Synonyms: kreatinine |
| ru-RU | Russian (Russian Federation) | Кокаин/Креатинин: Synonyms: Количественный Масс отношение Точка во времени; |
| tr-TR | Turkish (Turkey) | Kokain/Kreatinin: Synonyms: Teyid |
| zh-CN | Chinese (China) | 可卡因/肌酐: Synonyms: C17H21NO4; |
Example Units
| Unit | Source |
|---|---|
| ng/mg{creat} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
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