Version 2.78

Term Description

Quantitative result for Dengue virus 4 neutralizing antibodies in clinical specimens. Serological cross-reactivity is strong between Dengue and other flaviviruses, especially Zika virus. Therefore, positive EIA or IF assays are presumptive only and should be confirmed by a neutralization assay, such as the plaque-reduction neutralization test (PRNT), which can discriminate between Dengue virus and cross-reacting antibodies in primary flavivirus infections.
Source: Regenstrief LOINC

Part Descriptions

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

Fully-Specified Name

Component
Dengue virus 4 Ab.Neut
Property
Titr
Time
Pt
System
XXX
Scale
SemiQn
Method
Neut

Additional Names

Short Name
DENV4 NAb Titr Spec Nt
Display Name
DENV 4 neut ab Neut test (Specimen) [Titer]
Consumer Name Alpha Get Info
Dengue virus 4 neutralizing antibody, Specimen

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.75
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG32760-7 Dengue virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Dengue-Virus 4 Ak.neutralisierend:Titer:Zeitpunkt:XXX:Semiquantitativ:Neutralisationstest
es-ES Spanish (Spain) Virus Dengue 4 Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:XXX:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Virus del dengue 4 Ab.Neut:Título:Punto temporal:XXX:Cuantitativo:Prueba de neutralización
fr-CA French (Canada) Virus de la dengue 4 Ac.neut:Titre:Temps ponctuel:XXX:SemiQn:Test de neutralisation
fr-FR French (France) Dengue virus 4 Ac neutralisant:Titre:Ponctuel:Milieux divers:Semi-Quantitatif:Neutralisation
it-IT Italian (Italy) Dengue virus 4 Ab.Neut:Titr:Pt:XXX:SemiQn:Neut
Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo
nl-NL Dutch (Netherlands) Denguevirus 4 As.neutraliserend:titer:moment:XXX:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Wirus dengi 4 Ab.Neutralizujące:miano:punkt w czasie:XXX:półilościowy:test neutralizacji
Synonyms: Przeciwciała do wirusa dengi 4 Przeciwciała neutraliziujące do wirusa dengi 4 Wirus dengi Wirus dengi 4
zh-CN Chinese (China) 登革热病毒 4 型 抗体.中和:滴定度:时间点:XXX:半定量型:中和试验
Synonyms: Ab;自身抗体 DENV 4 Ab DENV 4 抗体 DENV 4;DENV IV;DENV4;登革热;登革热病毒 IV 型 DENV IV Ab DENV IV 抗体 DENV;地方性蔷薇疹热;登革热;登革病毒;黄病毒 DENV4 Ab DENV4 抗体 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 登革热病毒 4 型 Ab 登革热病毒 IV 型 Ab 登革热病毒 IV 型抗体

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86861-2