86897-6

inFLIXimab Ab [Mass/volume] in Serum or Plasma by Immunoassay

Active

Term Description

This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Infliximab and anti-Infliximab test kits.

Part Descriptions

LP158087-9 inFLIXimab Ab
Antibodies to infliximab (ATI) are detectable in 20% of pediatric and young adult patients taking infliximab. Patients with ATI have reduced levels of infliximab and a higher risk for surgery in patient with inflammatory bowel disease (IBD). When treatment with infliximab is combined with immunomodulators, the likelihood of developing ATI is reduced when compared to using infliximab alone. PMID: 25569737 Source: Regenstrief LOINC

LP35095-6 inFLIXimab
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: inFLIXimab Ab:MCnc:Pt:Ser/Plas:Qn:IA
Long Common Name: inFLIXimab Ab [Mass/volume] in Serum or Plasma by Immunoassay
Short Name: inFLIXimab Ab SerPl IA-mCnc
Display Name: inFLIXimab Ab IA [Mass/Vol]
Consumer Name Alpha Get Info: inFLIXimab antibody, Blood

Part Model Get Info

Component
inFLIXimab Ab
LP158087-9
- Analyte
  inFLIXimab Ab
  LP158087-9
  - Component Numerator
    inFLIXimab Ab
    LP158087-9
    - Component Numerator Core
      inFLIXimab
      LP35095-6
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.63
Last Updated: Version 2.63 (ADD)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG27918-8	Infliximab Ab\|MCnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
ar-JO	Arabic (Jordan)	قياس تركيز أضداد الإنفلكسيماب " ريميكيد " في المصل أو البلازما ( الكتلة / الحجم ) ( بتقنية المقايسة المناعية )
cs-CZ	Czech (Czechia)	Infliximab Ab:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Ινφλιξιμάμπη Αντίσωμα:MCnc:Pt:Ορός/Πλάσμα:Qn:IA Synonyms: DRUG/TOX IA MCnc Pt Qn Αντίσωμα Ινφλιξιμάμπη Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Infliximab Anticuerpos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	inFLIXimab Ab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
et-EE	Estonian (Estonia)	Infliksimaab antikehad:MCnc:Pt:S/P:Qn:IA Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA	French (Canada)	Infliximab, Ac:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-FR	French (France)	Infliximab Ac:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
fr-BE	French (Belgium)	Infliximab Ac:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Infliximab Ab:MCnc:Pt:Siero/Plasma:Qn:IA Synonyms: anticorpo Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL	Dutch (Netherlands)	infliximab As:massa/volume:moment:serum of plasma:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Infliksymab Ab:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:metoda immunologiczna Synonyms: Przeciwciała do Infliksymab
ru-RU	Russian (Russian Federation)	Инфликсимаб Ат:МассКонц:ТчкВрм:Сыв/Плаз:Колич:IA Synonyms: Антитело Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	İnfliksimab Ab:KütlKons:Zmlı:Ser/Plaz:Kant:İA Synonyms: Ak İmmünölçüm, immünoassay
zh-CN	Chinese (China)	英利昔单抗抗体:质量浓度:时间点:血清/血浆:定量型:免疫测定法 Synonyms: Ab;自身抗体 Infliximab 单抗;嵌合了肿瘤坏死因子α（TNF-α）的单克隆抗体;目前主要用于治疗类风湿性关节炎（RA）和克隆病（CD）;英利昔;英利昔单克隆抗体;因福利美;抗炎单克隆抗体免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
ng/mL	Example UCUM Units

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CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86897-6

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.