Version 2.80

Term Description

This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Infliximab and anti-Infliximab test kits.

Part Descriptions

LP158087-9   inFLIXimab Ab
Antibodies to infliximab (ATI) are detectable in 20% of pediatric and young adult patients taking infliximab. Patients with ATI have reduced levels of infliximab and a higher risk for surgery in patient with inflammatory bowel disease (IBD). When treatment with infliximab is combined with immunomodulators, the likelihood of developing ATI is reduced when compared to using infliximab alone. PMID: 25569737 Source: Regenstrief LOINC

LP35095-6   inFLIXimab
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638 Source: Regenstrief LOINC

Fully-Specified Name

Component
inFLIXimab Ab
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Long Common Name
inFLIXimab Ab [Mass/volume] in Serum or Plasma by Immunoassay
Short Name
inFLIXimab Ab SerPl IA-mCnc
Display Name
inFLIXimab Ab IA [Mass/Vol]
Consumer Name Alpha Get Info
inFLIXimab antibody, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG27918-8 Infliximab Ab|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ινφλιξιμάμπη Αντίσωμα:MCnc:Pt:Ορός/Πλάσμα:Qn:IA
Synonyms: MCnc Ινφλιξιμάμπη
es-ES Spanish (Spain) Infliximab Anticuerpos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) inFLIXimab Ab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
et-EE Estonian (Estonia) Infliksimaab antikehad:MCnc:Pt:S/P:Qn:IA
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Infliximab, Ac:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
Synonyms: #REF!
fr-FR French (France) Infliximab anticorps:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
fr-BE French (Belgium) Infliximab Ac:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
Synonyms: Anticorps
it-IT Italian (Italy) Infliximab Ab:MCnc:Pt:Siero/Plasma:Qn:IA
Synonyms: anticorpo Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) infliximab As:massa/volume:moment:serum of plasma:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
ru-RU Russian (Russian Federation) Инфликсимаб Ат:МассКонц:ТчкВрм:Сыв/Плаз:Колич:IA
Synonyms: Антитело Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) İnfliksimab Ab:KütlKons:Zmlı:Ser/Plaz:Kant:İA
Synonyms: İmmünölçüm, immünoassay
zh-CN Chinese (China) 英利昔单抗 抗体:质量浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: Ab;自身抗体 Infliximab 单抗;嵌合了肿瘤坏死因子α（TNF-α）的单克隆抗体;目前主要用于治疗类风湿性关节炎（RA）和克隆病（CD）;英利昔;英利昔单克隆抗体;因福利美;抗炎单克隆抗体 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86897-6