86899-2

Vedolizumab Ab [Mass/volume] in Serum or Plasma by Immunoassay

Active

Term Description

This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Vedolizumab and anti-Vedolizumab test kits.

Part Descriptions

LP250843-2 Vedolizumab
Vedolizumab is a monoclonal antibody used in the treatment of inflammatory bowel disease (IBD) including the subtypes Ulcerative colitis and Crohn's disease. IBD involves inflammation of the intestinal mucosa by leukocytes that cause a disruption in its barrier function. The leukocytes involved are T-cells that express α4β7 integrins which are the target for the drug vedolizumab. Vedolizumab prevents α4β7 integrin from binding with the endothelial surface and T-cells from penetrating the intestinal mucosa. Vedolizumab has proven to be a safe and effective treatment for IBD based in clinical research. Clinical studies have shown that vedolizumab helps achieve corticosteroid-free clinical remission. PMID: 27003961 Source: Regenstrief LOINC

LP250846-5 Vedolizumab Ab
In clinical trials, antibodies to vedolizumab (ATV) were present in about 4% of patients at any given time and were persistent in only 1% or less of patients receiving vedolizumab. https://www.healthcare.uiowa.edu/path_handbook/handbook/test3424.html In those patients with anti-vedolizumab antibodies, vedolizumab clearance was increased by about 12%, and for those with persistent antibodies, the trough concentration of vedolizumab was below detectable limits. Anti-drug antibodies can be one cause of treatment failure for vedolizumab as well as other monoclonal antibody therapeutics. PMID: 25996351 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Vedolizumab Ab:MCnc:Pt:Ser/Plas:Qn:IA
Long Common Name: Vedolizumab Ab [Mass/volume] in Serum or Plasma by Immunoassay
Short Name: Vedolizumab Ab SerPl IA-mCnc
Display Name: Vedolizumab Ab IA [Mass/Vol]
Consumer Name Alpha Get Info: Vedolizumab antibody, Blood

Part Model Get Info

Component
Vedolizumab Ab
LP250846-5
- Analyte
  Vedolizumab Ab
  LP250846-5
  - Component Numerator
    Vedolizumab Ab
    LP250846-5
    - Component Numerator Core
      Vedolizumab
      LP250843-2
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.63
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 6276

Member of these Panels

LOINC	Long Common Name
90794-9	Vedolizumab and Vedolizumab Ab panel [Mass/volume] - Serum or Plasma

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Vedolizumab Ab:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Βεδολιζουμάμπη Αντίσωμα:MCnc:Pt:Ορός/Πλάσμα:Qn:IA Synonyms: DRUG/TOX IA MCnc Pt Qn Αντίσωμα Βεδολιζουμάμπη Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Vedolizumab Anticuerpos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Vedolizumab Ab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FR	French (France)	Védolizumab Ac:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT	Italian (Italy)	Vedolizumab Ab:MCnc:Pt:Siero/Plasma:Qn:IA Synonyms: anticorpo Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN	Chinese (China)	维多珠单抗抗体:质量浓度:时间点:血清/血浆:定量型:免疫测定法 Synonyms: Ab;自身抗体免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 维多珠;Vedolizumab 单抗;维多株单抗;维多珠单克隆抗体药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
ng/mL	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86899-2

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.