87405-7

Certolizumab Ab [Units/volume] in Serum or Plasma by Immunoassay

Active

Term Description

This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Certolizumab and anti-Certolizumab test kits.

Part Descriptions

LP250847-3 Certolizumab
Certolizumab is a monoclonal antibody conjugated to polyethylene glycol used to treat Crohn's Disease (CD) and rheumatoid arthritis (RA). Certolizumab pegol binds to tumor necrosis factor alpha (TNFα), a pro-inflammatory cytokine that is implicated in the pathogenesis of a number of immunological diseases including CD and RA. TNFα mediates the signature inflammation-induced joint damage in RA. The reduction of TNFα alleviates symptoms of RA, CD and other immunologic diseases. TNFα-inhibitors have been hugely successful in treating immunological diseases. In spite of the positive impact TNFα-inhibitors have had there is still variability in response to their use including loss of response over time and drug tolerance. PMID: 20190560 Source: Regenstrief LOINC

LP250850-7 Certolizumab Ab
Antibodies to certolizumab were detected in about 22% of patients during a 7-year clinical trial of patients with Crohn's disease. Approximately 22% of antibody-positive patients had transient antibodies, and the rest had persistent anti-certolizumab antibodies. Those with persistent antibodies had lower plasma certolizumab concentration and drug efficacy compared to those with transient antibodies as well as those patients who were antibody-negative. PMID: 28410341 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Certolizumab Ab:ACnc:Pt:Ser/Plas:Qn:IA
Long Common Name: Certolizumab Ab [Units/volume] in Serum or Plasma by Immunoassay
Short Name: Certolizumab Ab SerPl IA-aCnc
Display Name: Certolizumab Ab IA Qn
Consumer Name Alpha Get Info: Certolizumab antibody, Blood

Part Model Get Info

Component
Certolizumab Ab
LP250850-7
- Analyte
  Certolizumab Ab
  LP250850-7
  - Component Numerator
    Certolizumab Ab
    LP250850-7
    - Component Numerator Core
      Certolizumab
      LP250847-3
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.63
Last Updated: Version 2.68 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Certolizumab Ab:Arbitrární koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Κερτολιζουμάμπη Αντίσωμα:ACnc:Pt:Ορός/Πλάσμα:Qn:IA Synonyms: ACnc DRUG/TOX IA Pt Qn Αντίσωμα Κερτολιζουμάμπη Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Certolizumab Anticuerpos:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Certolizumab Ab:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FR	French (France)	Certolizumab Ac:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT	Italian (Italy)	Certolizumab pegol Ab:ACnc:Pt:Siero/Plasma:Qn:IA Synonyms: anticorpo Certolizumab pegolo Concentrazione Arbitraria Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL	Dutch (Netherlands)	certolizumab As:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
zh-CN	Chinese (China)	塞妥珠单抗抗体:任意型浓度:时间点:血清/血浆:定量型:免疫测定法 Synonyms: Ab;自身抗体任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺塞妥珠单克隆抗体;塞妥珠;Certolizumab 单抗时刻;随机;随意;瞬间毒品毒品类药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.