87807-4
Naloxone [Mass/volume] in Saliva (oral fluid) by Confirmatory method
Active
Part Descriptions
LP28525-1 Naloxone
Naloxone is a pure opioid antagonist and, when taken at recommended doses, has no physiological effects in the absence of an opioid agonist. Intravenous naloxone becomes effective within two minutes of injection, but oral or sublingual naloxone has little effect due to its poor absorption. Therefore, intravenous naloxone is used to treat opioid overdose, and it is used as a sublingual combination with buprenorphine, an opioid agonist-antagonist used to treat chronic opioid-dependence, to lower buprenorphine's abuse potential as follows: when the combination is taken sublingually as prescribed, naloxone exerts little effect and buprenorphine's effects predominate; however, if crushed and injected intravenously, naloxone's antagonist properties reverse the agonist effects of buprenorphine and can precipitate withdrawal. PMID: 19368419 Nalaxone levels along with its inactive metabolite, naloxone-3-glucuronide (N3G), may be measured to monitor compliance or identify illicit opioid drug use.
Source: Regenstrief LOINC, PMID: 19368419
LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583
Source: Regenstrief LOINC
LP262420-5 Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Naloxone
- Property
- MCnc
- Time
- Pt
- System
- Saliva
- Scale
- Qn
- Method
- Confirm
Additional Names
- Short Name
- Naloxone Sal Cfm-mCnc
- Display Name
- Naloxone Confirm (Sal) [Mass/Vol]
- Consumer Name Alpha Get Info
- Naloxone, Saliva
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.63
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 6621
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG37627-3 | Naloxone| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Naloxona: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Naloxona: |
| et-EE | Estonian (Estonia) | Naloksoon: Synonyms: Juhuslik Kvantitatiivne Sülg |
| fr-CA | French (Canada) | Naloxone: |
| fr-FR | French (France) | Naloxone: |
| fr-BE | French (Belgium) | Naloxone: |
| it-IT | Italian (Italy) | Naloxone: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | naloxon: |
| ru-RU | Russian (Russian Federation) | Налоксон: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Nalokzon: Synonyms: Teyid |
| zh-CN | Chinese (China) | 钠洛酮: Synonyms: C19H21NO4; |
Example Units
| Unit | Source |
|---|---|
| ng/mL | Example UCUM Units |
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