88302-5
Lambda light chains.free [Presence] in 24 hour Urine by Immunofixation
Active
Part Descriptions
LP29082-2 Immunoglobulin light chains.lambda.free
Healthy patients have the majority of light chains in serum bound to heavy chains. Low levels of free light chains (unbound) are normal due to the over-production and secretion of free light chains by plasma cells. In the kidneys, the free light chains are selectively reabsorbed by the tubular cells, so their presence in urine is likely due to secretion into the urinary tract. Elevation of monoclonal free light chains in serum or urine signal malignant plasma cell proliferation (multiple myeloma), primary amyloidosis, or light chain deposition disease. Elevation of polyclonal free light chains suggests autoimmune diseases such as systemic lupus erythematosus. (Information from Freelite Beckman Coulter IMMAGE II package insert, Version 23, Feb 2009)
Source: Regenstrief Institute
LP6336-4 Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:
• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.
Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis.
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Source: Wikipedia, Immunofixation
Fully-Specified Name
- Component
- Immunoglobulin light chains.lambda.free
- Property
- PrThr
- Time
- 24H
- System
- Urine
- Scale
- Ord
- Method
- Immunofixation
Additional Names
- Short Name
- Lambda LC Free 24h Ur Ql IFE
- Display Name
- Immunoglobulin light chains.lambda.free Immunofixation Ql (24H U)
- Consumer Name Alpha Get Info
- Free lambda light chains, Urine
Example Answer List: LL744-4
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
Detected | LA11882-0 | ||
Not detected | LA11883-8 |
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64
- Order vs. Observation
- Both
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG36223-2 | Immunoglobulin light chains.lambda.free| |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Cadenas ligeras lambda libres: |
es-MX | Spanish (Mexico) | Cadenas ligeras de inmunoglobulina lambda.libre: |
et-EE | Estonian (Estonia) | Immuunglobuliinide kerged lambdaahelad: Synonyms: Immuunglobuliinide kerged lambdaahelad Järgarvuline Uriin |
fr-CA | French (Canada) | Chaînes légères des immunoglobulines.lambda.libre: |
fr-FR | French (France) | Immunoglobuline chaines légères libres lambda: |
fr-BE | French (Belgium) | Chaînes légères des immunoglobulines.lambda.libre: Synonyms: FLC.lambda.libre, FLC.lambda LC LC. Lambda |
it-IT | Italian (Italy) | Immunoglobuline, catene leggere.lambda.libere: Synonyms: 24 Ore Catene leggere delle immunoglobuline Catene leggere lambda delle immunoglobuline Catene leggere lambda libere delle immunoglobuline Chimica Presenza o Soglia |
nl-NL | Dutch (Netherlands) | immunoglobuline lichte ketens.lambda.vrij: Synonyms: 24U |
pl-PL | Polish (Poland) | Łańcuchy lekkie immunoglobulin.lambda.wolne: Synonyms: Łańcuchy lekkie immunoglobulin Łańcuchy lekkie lambda immunoglobuliny Łańcuchy lekkie wolne lambda |
ru-RU | Russian (Russian Federation) | Иммуноглобулин легкие цепи.лямбда.свободная: Synonyms: Порядковый |
tr-TR | Turkish (Turkey) | İmmünglobulin hafif zincirler.lambda.serb: Synonyms: Mevcut |
zh-CN | Chinese (China) | 免疫球蛋白轻链.Lambda 型.游离型: Synonyms: 1天; |
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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright