88517-8

Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] corrected for background in Blood

Active

Term Description

The quantitative levels (corrected for background) for an IFN-gamma response by CD4+ T-helper and CD8+ T cytotoxic lymphocytes stimulated by the presence of TB antigens, specifically ESAT-6 and CFP-10. This term was created for, but not limited in use to, the QuantiFERON-TB Gold Plus test, which includes two tubes with the Mycobacterium tuberculosis (MTB)-complex-associated antigens ESAT-6 and CFP-10 that stimulate a cell-mediated immunity (CMI) response. The first tube contains antigens that stimulate a response from CD4+ T-helper lymphocytes LOINC 64084-7, and the second tube (this term) contains the antigens included in tube 1 as well as an additional set of peptides targeting the CMI response from CD8+ cytotoxic T lymphocytes. In the QuantiFERON-TB Gold Plus test, the amount of IFN-gamma is measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.

Part Descriptions

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2 CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background:ACnc:Pt:Bld:Qn:
Long Common Name: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] corrected for background in Blood
Short Name: M TB IFN-g CD4+CD8+ bckgrnd cor Bld-aCnc
Display Name: M. tuberculosis stim IFN-g by CD4+ CD8+ T-cells corrected for background Qn (Bld)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells Corrected for Background, Blood

Part Model Get Info

Component
Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background
LP308391-4
- Analyte
  Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells
  LP265738-7
  - Component Numerator
    Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells
    LP265738-7
    - Component Numerator Core
      Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells
      LP265738-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  corrected for background
  LP115711-6
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld
LP7057-5
- System Core
  Bld
  LP7057-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.73 (MIN)
Change Reason: Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background to be consistant with LOINC cell marker naming conventions.
Order vs. Observation: Both
Common Test Rank Get Info: 620

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Interferon gama po stimulaci Mycobacterium tuberculosis uvolnění pomocí CD4+ a CD8+ T-buněk^^s korekcí pozadí:Arbitrární koncentrace:Časový bod:Krev:Kvantitativní:
de-DE	German (Germany)	Mycobacterium-tuberculosis-stimulierte Gamma-Interferon-Freisetzung durch CD4+- und CD8+-T-Zellen^^Korrektur des Hintergrundsignals:Arbiträre Konzentration:Zeitpunkt:Blut:Quantitativ:
el-GR	Greek (Greece)	Απελευθέρωση από CD4+ και CD8+ Τ-κύτταρα διεγερμένης από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνης^^διορθωμένο για φόντο:ACnc:Pt:Αίμα:Qn: Synonyms: ACnc CD4 CD8 MICRO Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Pt Qn Αίμα Απελευθέρωση από CD4+ και CD8+ Τ-κύτταρα διεγερμένης από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνης Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη διορθωμένο για φόντο Ιντερφερόνη Κύτταρα
es-ES	Spanish (Spain)	IFNγ liberado por células T CD4 y T CD8 estimuladas por Mycobacterium tuberculosis^^Corregido por ruido de fondo:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 + y CD8 +^^ corregido para antecedentes:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma libéré par cellules T CD4+ et CD8+ stimulées par mycobacterium tuberculosis^^corrigé par le bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ e CD8+ e cellule T^^corretto per background:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+ en CD8+T-cellen^^gecorrigeerd voor achtergrond:eenheid/volume:moment:bloed:kwantitatief:
pl-PL	Polish (Poland)	Stymulacja przez Mycobacterium tuberculosis uwalniania interferonu gamma przez komórki T CD4+ i CD8+^^skorygowany względem tła:stężenie w jednostkach umownych:punkt w czasie:krew:ilościowy: Synonyms: CD4 CD8 IFN-gamma stymulowany Mycobacterium tuberculosis Prątek gruźlicy
zh-CN	Chinese (China)	CD4+ 和 CD8+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素^^经过针对本底而校正的:任意型浓度:时间点:全血:定量型: Synonyms: AFB CD4+ 和 CD8+ T-细胞（CD4+ 和 CD8+ T细胞、CD4+ 和 CD8+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu2 Leu-2 Leu3 Leu-3 T4 T-4 T8 T-8 Tsuppressor W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度分支杆菌分支杆菌属分枝杆菌属劳瘵发现于抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抑制性 T 细胞抑制性 T-细胞抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病细胞含量;细胞性;细胞性质;细胞构成;细胞类经过针对背景而校正的结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液诱导 T 细胞诱导性 T 细胞辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.