Version 2.78

Term Description

The quantitative levels (uncorrected for background) for an IFN-gamma response by CD4+ T-helper and CD8+ T cytotoxic lymphocytes stimulated by the presence of TB antigens, specifically ESAT-6 and CFP-10. This term was created for, but not limited in use to, the QuantiFERON-TB Gold Plus test, which includes two tubes with the Mycobacterium tuberculosis (MTB)-complex-associated antigens ESAT-6 and CFP-10 that stimulate a cell-mediated immunity (CMI) response. The first tube contains antigens that stimulate a response from CD4+ T-helper lymphocytes [LOINC: 64084-7], and the second tube (this term) contains the antigens included in tube 1 as well as an additional set of peptides targeting the CMI response from CD8+ cytotoxic T lymphocytes. In the QuantiFERON-TB Gold Plus test, the amount of IFN-gamma is measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.
Source: Regenstrief LOINC

Part Descriptions

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells
Property
ACnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
M TBIFN-g CD4+ CD8+T-cells Bld-aCnc
Display Name
M. tuberculosis stim IFN-g by CD4+ CD8+ T-cells Qn (Bld)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Change Reason
Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells to be consistant with LOINC cell marker naming conventions.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
71775-1 Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) IFNγ liberado por células T CD4 y T CD8 estimuladas por Mycobacterium tuberculosis:Concentración arbitraria:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 + y CD8 +:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) Interféron gamma libéré par cellules T CD4+ et CD8+ stimulées par mycobacterium tuberculosis:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ e CD8+ e cellule T:ACnc:Pt:Sangue:Qn:
Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+ en CD8+T-cellen:eenheid/volume:moment:bloed:kwantitatief:
zh-CN Chinese (China) CD4+ 和 CD8+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素:任意型浓度:时间点:全血:定量型:
Synonyms: AFB CD4+ 和 CD8+ T-细胞（CD4+ 和 CD8+ T细胞、CD4+ 和 CD8+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu2 Leu-2 Leu3 Leu-3 T4 T-4 T8 T-8 Tsuppressor W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 分支杆菌 分支杆菌属 分枝杆菌属 劳瘵 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 抑制性 T 细胞 抑制性 T-细胞 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 时刻;随机;随意;瞬间 痨 痨病 细胞含量;细胞性;细胞性质;细胞构成;细胞类 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） 结核病 肺结核 血;血液 诱导 T 细胞 诱导性 T 细胞 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞

Example Units

Unit Source
[IU]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88518-6