LOINC
Version 2.72

88535-0Cytomegalovirus DNA [Presence] in DBS by NAA with probe detectionActive

Term Description

Cytomegalovirus (CMV) DNA in dried blood spots can be used for retrospective diagnosis of congenital CMV, for example, in patients with unexplained childhood-onset hearing loss. Utility of the test in newborn screening for CMV infection has not been established. [PMID:25889596] Dried blood spot testing may also be used to monitor immunocompromised patients, such as those who have undergone organ transplant. [PMID:24483296]
Source: Regenstrief LOINC

Part Description

LP14255-1   Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Cytomegalovirus DNA
Property
PrThr
Time
Pt
System
Bld.dot
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
CMV DNA DBS Ql NAA+probe
Display Name
CMV DNA NAA+probe Ql (DBS)
Consumer Name Alpha
Cytomegalovirus (CMV), Dried blood spot

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
巨细胞病毒 DNA:存在情况或阈值:时间点:全血.斑点:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
Cytomegalovirus DNA:aanwezigheid:moment:gedroogde bloedspot:ordinaal:moleculaire techniek (PCR)
fr-BEFrench (Belgium)
Cytomégalovirus ADN:PrThr:Temps ponctuel:Sang sur papier filtre:Ordinal:Sonde avec amplification de la cible
fr-CAFrench (Canada)
Cytomégalovirus , ADN:Présence-Seuil:Temps ponctuel:Sang sur papier filtre:Ordinal:Sonde avec amplification de la cible
fr-FRFrench (France)
Cytomégalovirus ADN:Présence/Seuil:Ponctuel:Sang buvard:Qualitatif:PCR amplification de cible
de-DEGerman (Germany)
Cytomegalievirus DNA:Nachweis oder Schwellenwert:Zeitpunkt:Blut.Tropfen:Ordinal:Zielfragmentamplifikation mit Sondendetektion
it-ITItalian (Italy)
Citomegalovirus DNA:PrThr:Pt:Sangue.su carta da filtro:Ord:Sonda.amp.tar
ru-RURussian (Russian Federation)
Цитомегаловирус ДНК:PrThr:ТчкВрм:Кр.Сух.капл:Пор:Проба.усил.миш
es-MXSpanish (Mexico)
ADN de citomegalovirus:Presencia o umbral:Punto temporal:DBS:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Citomegalovirus ADN:PrThr:Punto temporal:gota de sangre (papel de filtro):Ord:Sonda con amplificación dirigida
tr-TRTurkish (Turkey)
Cytomegalovirus DNA:MevcEşik:Zmlı:Kan.nokta:Srl:Prob.amf.hdf

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88535-0