88544-2

HIV 1 RNA reverse transcriptase gene mutations detected [Identifier] in Cerebrospinal Fluid by Sequencing

Active

Term Description

Used to determine HIV 1 RNA resistance in CSF samples from patients with neurological symptoms of HIV who may have CSF/plasma discordance in the amount of circulating virus as well as resistance patterns. PMID: 25344810

Part Description

LP150045-5 Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: HIV 1 RNA reverse transcriptase gene mutations detected:Prid:Pt:CSF:Nom:Sequencing
Long Common Name: HIV 1 RNA reverse transcriptase gene mutations detected [Identifier] in Cerebrospinal Fluid by Sequencing
Short Name: HIV 1 RNA RT Mut Det CSF Seq
Display Name: HIV 1 RNA RT mutations detected Sequencing Nom (CSF)
Consumer Name Alpha Get Info: HIV 1 RNA RT variant analysis, Spinal fluid

Part Model Get Info

Component
HIV 1 RNA reverse transcriptase gene mutations detected
LP265775-9
- Analyte
  HIV 1 RNA reverse transcriptase gene mutations detected
  LP265775-9
  - Component Numerator
    HIV 1 RNA reverse transcriptase gene mutations detected
    LP265775-9
    - Component Numerator Core
      HIV 1 RNA reverse transcriptase gene
      LP265776-7
    - Component Numerator Core Suffix
      mutations detected
      LP32420-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Prid
LP6850-4
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
CSF
LP7156-5
- System Core
  CSF
  LP7156-5
- Super System
  NULL
Scale
Nom
LP7750-5
Method
Sequencing
LP150045-5

Example Answer List: LL4854-7

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
K13K/E HIV mutation in the reverse transcriptase (RT) coding region			LA19752-7
K20R HIV mutation in the reverse transcriptase (RT) coding region			LA19753-5
E28D HIV mutation in the reverse transcriptase (RT) coding region			LA19754-3
M41M/L HIV mutation in the reverse transcriptase (RT) coding region			LA19755-0
G359S HIV mutation in the reverse transcriptase (RT) coding region			LA25848-5
V35I HIV mutation in the reverse transcriptase (RT) coding region			LA25847-7

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.83 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	HIV 1 RNA reverzní transkriptáza genové mutace detekované:Přítomnost nebo identita:Časový bod:Mozkomíšní mok:Nominální:Sekvenace
el-GR	Greek (Greece)	Γονίδιο αντίστροφης μεταγραφάσης RNA του ιού της ανθρώπινης ανοσοανεπάρκειας 1 ανιχνευθείσες μεταλλάξεις:Prid:Pt:ΕΝΥ:Nom:Αλληλούχιση Synonyms: ABXBACT HIV 1 Nom Prid Pt RNA RNA ιού της ανθρώπινης ανοσοανεπάρκειας 1 Αλληλούχιση ανιχνευθείσες μεταλλάξεις Γονίδιο Γονίδιο αντίστροφης μεταγραφάσης RNA του ιού της ανθρώπινης ανοσοανεπάρκειας 1 ΕΝΥ Ιός ανθρώπινης ανοσοανεπάρκειας Μεταλλάξεις
es-ES	Spanish (Spain)	Gen transcriptasa inversa VIH1 RNA Detección de mutaciones:Presencia o identidad:Punto temporal:Líquido Cefalorraquideo:Nom:Secuenciación
es-MX	Spanish (Mexico)	Se detectaron mutaciones en el gen de la transcriptasa inversa del ARN del VIH 1:Presencia o identidad:Punto temporal:Fluído espinal cerebral:Nominal:Secuenciación
fr-FR	French (France)	VIH-1 ARN gène de la réverse transcriptase mutations détectées:Identification:Ponctuel:Liquide céphalorachidien:Résultat nominal:Séquençage
it-IT	Italian (Italy)	HIV 1 RNA, gene trascrittasi inversa, mutazioni identificate:Prid:Pt:LCS:Nom:Sequenziamento Synonyms: Liquido cerebrospinale Presenza o Identità Punto nel tempo (episodio) RNA dell''HIV 1 Suscettibilità agli antibiotici
pl-PL	Polish (Poland)	Odwrotna transkryptaza HIV 1 RNA gen wykryte mutacje:obecność lub identyfikacja:punkt w czasie:płyn mózgowo-rdzeniowy:skala nominalna:sekwencjonowanie Synonyms: Gen odwrotnej transkryptazy RNA ludzkiego wirusa niedoboru odporności typu 1;Gen odwrotnej transkryptazy RNA HIV 1 Ludzki wirus niedoboru odporności Ludzki wirus niedoboru odporności typu 1 RNA ludzkiego wirusa niedoboru odporności typu 1 wynik kategorialny
zh-CN	Chinese (China)	HIV 1 型 RNA 逆转录酶基因已检出的突变:存在与否或特征标识:时间点:脑脊液:名义型:序列测定 Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） RNA（核糖核酸）逆转录酶（反转录酶、逆录酶、RT）基因 HIV1 RNA HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I RT RTase 倒倒的倒转倒转的分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答反向反向的反常反常的反的反相反相的反转录酶存在;存在与否;特征标识;身份;身份标识已发现的突变序列分析;测序抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 相反相反的突变突变类;基因突变脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液逆逆的逆转录酶（Reverse transcriptase，RT）遗传基因;遗传因子;吉恩;生物基因颠倒颠倒的

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.