88544-2

HIV 1 RNA reverse transcriptase gene mutations detected [Identifier] in Cerebral spinal fluid by Sequencing

Active

Term Description

Used to determine HIV 1 RNA resistance in CSF samples from patients with neurological symptoms of HIV who may have CSF/plasma discordance in the amount of circulating virus as well as resistance patterns. PMID: 25344810
Source: Regenstrief LOINC

Part Description

LP150045-5 Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

Fully-Specified Name

Component: HIV 1 RNA reverse transcriptase gene mutations detected
Property: Prid
Time: Pt
System: CSF
Scale: Nom
Method: Sequencing

Additional Names

Short Name: HIV 1 RNA RT Mut Det CSF Seq
Display Name: HIV 1 RNA RT mutations detected Sequencing Nom (CSF)
Consumer Name Alpha Get Info: HIV 1 RNA RT variant analysis, Spinal fluid

Example Answer List: LL4854-7

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
K13K/E HIV mutation in the reverse transcriptase (RT) coding region			LA19752-7
K20R HIV mutation in the reverse transcriptase (RT) coding region			LA19753-5
E28D HIV mutation in the reverse transcriptase (RT) coding region			LA19754-3
M41M/L HIV mutation in the reverse transcriptase (RT) coding region			LA19755-0
G359S HIV mutation in the reverse transcriptase (RT) coding region			LA25848-5
V35I HIV mutation in the reverse transcriptase (RT) coding region			LA25847-7

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.64
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Gen transcriptasa inversa VIH1 RNA Detección de mutaciones:Presencia o identidad:Punto temporal:Líquido Cefalorraquideo:Nom:Secuenciación
es-MX	Spanish (Mexico)	Se detectaron mutaciones en el gen de la transcriptasa inversa del ARN del VIH 1:Presencia o identidad:Punto temporal:Fluído espinal cerebral:Nominal:Secuenciación
fr-FR	French (France)	VIH-1 ARN gène reverse transcriptase mutations détectées:Identification:Ponctuel:Liquide céphalorachidien:Résultat nominal:Séquençage
it-IT	Italian (Italy)	HIV 1 RNA, gene trascrittasi inversa, mutazioni identificate:Prid:Pt:LCS:Nom:Sequenziamento Synonyms: Liquido cerebrospinale Presenza o Identità Punto nel tempo (episodio) RNA dell''HIV 1 Suscettibilità agli antibiotici
zh-CN	Chinese (China)	HIV 1 型 RNA 逆转录酶基因已检出的突变:存在与否或特征标识:时间点:脑脊液:名义型:序列测定 Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） RNA（核糖核酸）逆转录酶（反转录酶、逆录酶、RT）基因 HIV1 RNA HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I RT RTase 倒倒的倒转倒转的分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答反向反向的反常反常的反的反相反相的反转录酶存在;存在与否;特征标识;身份;身份标识已发现的突变序列分析;测序抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 相反相反的突变突变类;基因突变脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液逆逆的逆转录酶（Reverse transcriptase，RT）遗传基因;遗传因子;吉恩;生物基因颠倒颠倒的

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