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Term Description

The is a qualitative test using a reverse transcriptase PCR for a vaccine strain-specific nucleic acid sequence within the nucleoprotein (N) gene of Measles virus A, in various clinical samples or from cell culture.

Part Description

LP266148-8   Measles virus genotype A vaccine strain N gene
The measles virus (MeV) is a single-stranded, enveloped RNA virus and a member of the Paramyxoviridae family. Measles was first discovered to be caused by an infectious agent in 1757 by a Scottish physician. After becoming a notifiable disease in the United States in 1912, there were roughly 6,000 deaths reported each year in the following ten years due to MeV. The vaccination against MeV become available in the United States in 1963 which caused a rapid drop in MeV infections. MeV is highly contagious and is transmitted through infected secretions. Symptoms of infection include fever, malaise, cough, coryza, and conjunctivitis. Later, pathognomonic enanthema (Koplik spots) develop and are followed by a maculopapular rash that appears 14 days after exposure to MeV and spreads from the head, down the trunk, and to the lower extremities. Patients susceptible to serious complications may experience acute encephalitis and subsequent brain damage, fatal respiratory and neurologic complications, or a rare, fatal degenerative disease of the central nervous system characterized by behavioral and intellectual deterioration and seizures that begin 7-10 years after the measles infection. There are 24 genotypes of MeV recognized by the World Health Organization that are categorized by the nucleotide sequences of their hemagglutinin (H) and nucleoprotein (N) genes. The region of the N gene that distinguishes between the genotypes is a 450 nucleotide sequence of the carboxyl terminus referred to as N-450. Sequencing the N-450 region can identify the genotype of the infecting virus. Because infection by MeV vaccine is sometimes given as a post-exposure prophylactic, it has become important to differentiate MeV wild-type infections from the virus present in the vaccine.Vaccine strains all belong to genotype A and the wild-type genotype A MeV strains are believed to no longer be circulating. That being the case, if a patient tests positive for genotype A, then the virus is most likely due to the vaccine.Also, the region of the N gene between nucleotides 478 and 548 is identical for all genotype A vaccine strains that have been analyzed, and PCR-based assays have been developed based on that region so that genotype A vaccine strains can be identified without having to sequence the entire gene.https://www.cdc.gov/measles/hcp/index.htmlhttp://jcm.asm.org/content/55/3/686.full Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Measles virus genotype A vaccine strain N gene:PrThr:Pt:XXX:Ord:Probe.amp.tar
Long Common Name
Measles virus genotype A vaccine strain N gene [Presence] in Specimen by NAA with probe detection
Short Name
MeVA vac str N gene Spec Ql NAA+probe
Display Name
MeV genotype A vaccine strain N gene NAA+probe Ql (Specimen)
Consumer Name Alpha Get Info
Measles virus Genotype A Vaccine Strain N gene, Specimen

Part Model Get Info

  • Component
    Measles virus genotype A vaccine strain N gene
    LP266148-8
    • Analyte
      Measles virus genotype A vaccine strain N gene
      LP266148-8
      • Component Numerator
        Measles virus genotype A vaccine strain N gene
        LP266148-8
        • Component Numerator Core
          Measles virus genotype A vaccine strain N gene
          LP266148-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    XXX
    LP7735-6
    • System Core
      XXX
      LP7735-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Probe.amp.tar
    LP6464-4

Example Answer List: LL3596-5

Source: New York State Health (Wadsworth Center)
AnswerCodeScoreAnswer ID
DetectedLA11882-0
Not detectedLA11883-8
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value)LA9663-1

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.81 (MIN)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG32756-5Measles virus

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Virus spalniček vakcinační kmen genotyp A gen N:Přítomnost nebo práh:Časový bod:XXX:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
el-GRGreek (Greece)Γονότυπος Α του ιού της ιλαράς, γονίδιο Ν του στελέχους του εμβολίου:PrThr:Pt:XXX:Ord:Ανιχνευτής.ενίσχυση.στόχου
Synonyms: A MICRO N Ord PrThr Pt XXX Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Γονίδιο Γονότυπος Α του ιού της ιλαράς, γονίδιο Ν του στελέχους του εμβολίου Ιός Ιός ιλαράς
es-ESSpanish (Spain)Vacuna contra la cepa del Virus de sarampión genotipo A del gen N:PrThr:Punto temporal:XXX:Ord:Sonda con amplificación dirigida
es-MXSpanish (Mexico)Genotipo A del virus del sarampión, cepa N de la vacuna:Presencia o umbral:Punto temporal:XXX:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-CAFrench (Canada)Rougeole virus génotype A souche vaccinale gène N:Présence-Seuil:Temps ponctuel:XXX:Ordinal:Sonde avec amplification de la cible
fr-FRFrench (France)Rougeole virus génotype A souche vaccinale gène N:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:PCR amplification de cible
it-ITItalian (Italy)Morbillo virus genotipo A ceppo vaccinale, gene N:PrThr:Pt:XXX:Ord:Sonda.amp.tar
Synonyms: Gene N virus del Morbillo genotipo A ceppo vaccinale Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus di morbillo
pl-PLPolish (Poland)Wirus odry genotyp A szczep szczepionkowy N gen:granica wykrywalności:punkt w czasie:XXX:uporządkowany:sonda.amplifikacja.cel
Synonyms: amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy Genotyp wirusa odry Szczep szczepionkowy wirusa odry genotypu A zawierający gen N Wirus odry
zh-CNChinese (China)麻疹病毒基因型 A 疫苗株 N 基因:存在情况或阈值:时间点:XXX:序数型:探针法.基因扩增.靶向
Synonyms: A 型 MeV;Msls;风疹;麻疹 N 型 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 遗传基因;遗传因子;吉恩;生物基因 麻疹病毒（MeV）基因型 A 疫苗株 N 基因;麻疹病毒（MeV）基因型 A 疫苗 N 株基因

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