Version 2.78

Term Description

The is a qualitative test using a reverse transcriptase PCR for a vaccine strain-specific nucleic acid sequence within the nucleoprotein (N) gene of Measles virus A, in various clinical samples or from cell culture.
Source: Regenstrief LOINC

Part Description

LP266148-8   Measles virus genotype A vaccine strain N gene
The measles virus (MeV) is a single-stranded, enveloped RNA virus and a member of the Paramyxoviridae family. Measles was first discovered to be caused by an infectious agent in 1757 by a Scottish physician. After becoming a notifiable disease in the United States in 1912, there were roughly 6,000 deaths reported each year in the following ten years due to MeV. The vaccination against MeV become available in the United States in 1963 which caused a rapid drop in MeV infections. MeV is highly contagious and is transmitted through infected secretions. Symptoms of infection include fever, malaise, cough, coryza, and conjunctivitis. Later, pathognomonic enanthema (Koplik spots) develop and are followed by a maculopapular rash that appears 14 days after exposure to MeV and spreads from the head, down the trunk, and to the lower extremities. Patients susceptible to serious complications may experience acute encephalitis and subsequent brain damage, fatal respiratory and neurologic complications, or a rare, fatal degenerative disease of the central nervous system characterized by behavioral and intellectual deterioration and seizures that begin 7-10 years after the measles infection. There are 24 genotypes of MeV recognized by the World Health Organization that are categorized by the nucleotide sequences of their hemagglutinin (H) and nucleoprotein (N) genes. The region of the N gene that distinguishes between the genotypes is a 450 nucleotide sequence of the carboxyl terminus referred to as N-450. Sequencing the N-450 region can identify the genotype of the infecting virus. Because infection by MeV vaccine is sometimes given as a post-exposure prophylactic, it has become important to differentiate MeV wild-type infections from the virus present in the vaccine.Vaccine strains all belong to genotype A and the wild-type genotype A MeV strains are believed to no longer be circulating. That being the case, if a patient tests positive for genotype A, then the virus is most likely due to the vaccine.Also, the region of the N gene between nucleotides 478 and 548 is identical for all genotype A vaccine strains that have been analyzed, and PCR-based assays have been developed based on that region so that genotype A vaccine strains can be identified without having to sequence the entire gene.[https://www.cdc.gov/measles/hcp/index.html][http://jcm.asm.org/content/55/3/686.full] Source: Regenstrief LOINC

Fully-Specified Name

Component
Measles virus genotype A vaccine strain N gene
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
MeVA vac str N gene Spec Ql NAA+probe
Display Name
MeV genotype A vaccine strain N gene NAA+probe Ql (Specimen)
Consumer Name Alpha Get Info
Measles virus Genotype A Vaccine Strain N gene, Specimen

Example Answer List: LL3596-5

Source: New York State Health (Wadsworth Center)
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value) LA9663-1

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.69
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG32756-5 Measles virus

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Vacuna contra la cepa del Virus de sarampión genotipo A del gen N:PrThr:Punto temporal:XXX:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Genotipo A del virus del sarampión, cepa N de la vacuna:Presencia o umbral:Punto temporal:XXX:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Rougeole virus génotype A souche vaccinale gène N:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Morbillo virus genotipo A ceppo vaccinale, gene N:PrThr:Pt:XXX:Ord:Sonda.amp.tar
Synonyms: Gene N virus del Morbillo genotipo A ceppo vaccinale Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus di morbillo
zh-CN Chinese (China) 麻疹病毒基因型 A 疫苗株 N 基因:存在情况或阈值:时间点:XXX:序数型:探针法.基因扩增.靶向
Synonyms: A 型 MeV;Msls;风疹;麻疹 N 型 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分子病理学;分子病理学试验 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 遗传基因;遗传因子;吉恩;生物基因 麻疹病毒（MeV）基因型 A 疫苗株 N 基因;麻疹病毒（MeV）基因型 A 疫苗 N 株基因

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