Version 2.78

Term Description

The omega-3 index, defined as eicosapentaenoate (EPA)+ docosahexaenoate (DHA)/Fatty acids.C14-C24, is a clinically useful measurement for evaluating blood levels of EPA and DHA. There are many health benefits from maintaining a good level of omega-3 fatty acids including reduced inflammation, risk of heart disease, cancer, arthritis, and many more. Deficiency in omega-3 fatty acids can result in fatigue, poor memory, dry skin, heart problems, mood swings, and poor circulation.[https://www.umm.edu/health/medical/altmed/supplement/omega3-fatty-acids] There have been a number of clinical trials to determine the effect of omega-3 supplementation based on a 1g/day dose of EPA, which successfully increased the total omega-3 level to >5% for 84% of the study participants. The remaining 16% had levels below 5%, which is the threshold at which significant reduction in sudden coronary death reduction is evident. The variability in the blood levels of omega-3 in patients who received the same supplemental dose of omega-3 has been attributed to genetic differences in fatty acid metabolism, body weight, baseline omega-3 level, age, gender, and physical activity. PMID: 25285179
Source: Regenstrief LOINC

Part Descriptions

LP266157-9   Eicosapentaenoate+Docosahexaenoate
Eicosapentaenoate (EPA) is a long chain omega-3 fatty acid that is present throughout the body including in cell membranes. EPA is found in fatty fish including salmon, tuna, mackerel, sardines, shellfish, and herring. EPA can be biosynthesized from alpha-linolenic acid (ALA), but it is much more efficient to increase levels by including EPA-rich sources in one's diet. EPA has anti-inflammatory properties that are vital to fetal development and the process of healthy aging. Its anti-inflammatory effects are due to reduced gene expression of genes involved in inflammatory and atherogenesis-related pathways, thereby lowering the risk of cardiovascular disease. EPA has also been found to increase platelet stability, decrease endothelial activation, and improve vascular permeability. Taking EPA supplements leads to an increased amount of EPA in the plaque of carotid arteries which may decrease inflammation and increase plaque stability. PMID: 22332096 Many other studies have been run that show acorrelation between higher plasma levels of EPA and reduced symptoms of disease, some of which include Alzheimer's disease, depression, rheumatoid arthritis, and Raynaud Syndrome.[ http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000301] Source: Regenstrief LOINC

LP266157-9   Eicosapentaenoate+Docosahexaenoate
Docosahexaenoate (DHA) is one of the essential polyunsaturated omega-3 fatty acids that is primarily obtained by ingesting fatty fish including salmon, mackerel, tuna, herring, and sardines.[https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/] There are many benefits derived from eating healthy levels of DHA including a reduction of chronic inflammation, atherosclerosis, hypertension, arthritis, depression, adult-onset diabetes mellitus, myocardial infarction, thrombosis, and some cancers. DHA is important in brain development of infants and in maintaining normal brain function in adults. Studies have demonstrated that infants who drink DHA-fortified formula have higher visual acuity than infants who drink unfortified formula. Deficiencies of DHA have been associated with fetal alcohol syndrome, attention deficit hyperactivity disorder, cystic fibrosis, phenylketonuria, unipolar depression, aggressive hostility, adrenoleukodystrophy, cognitive decline in aging individuals, and the onset of sporadic Alzheimer's disease. Patients who consume 200 mg/day of DHA have a 50% reduction in the incidence of sudden cardiac arrest. PMID: 10479465 Source: Regenstrief LOINC

LP266322-9   Fatty acids.C14-C24
Fatty acids are molecules made up of an even number of carbon atoms (in humans) numbering from 4 to 30. Depending on the number of carbon atoms, the fatty acids are members of one of three groups which includes the short chain fatty acids, the medium chain fatty acids, and the long chain fatty acids. Fatty acids are described by the number of carbon atoms, the number of double bonds, and the position of the double bonds. While there is evidence that certain fatty acids affect the risk of some chronic diseases, no reference ranges have been defined. PMID: 25675440 [http://www.cyberlipid.org/fa/acid0001.htm] Source: Regenstrief LOINC

Fully-Specified Name

Component
Eicosapentaenoate+Docosahexaenoate/Fatty acids.C14-C24
Property
SFr
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Omega-3 index SFr SerPl
Display Name
EPA+DHA/Fatty acids.C14-C24 [Molar fraction]
Consumer Name Alpha Get Info
EPA+DHA/Fatty Acids.C14-C24, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
13301

Member of these Panels

LOINC Long Common Name
88884-2 Fatty acid omega-3 and omega-6 panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Eicosapentaenoato + Docosahexaenoato/Ácidos grasos C14-C24:Fraccion de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Eicosapentaenoato + Docosahexaenoato / Ácidos grasos. C14-C24:Fracción de sustancia:Punto temporal:Suero o Plasma:Cuantitativo:
fr-FR French (France) Eicosapentaénoate+docosahexaénoate/acides gras C14-C24:Fraction molaire:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Eicosapentaenoato+Docosaesaenoato/Acidi grassi.C.14-C24:SFr:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Docosaesaenoato (C22:6w3) Eicosapentaenoato (C20:5w3) Frazione di Sostanza Plasma Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 二十碳五烯酸+二十二碳六烯酸/脂肪酸类.C14-C24:物质的量分数:时间点:血清/血浆:定量型:
Synonyms: C20:5w3;EPA;二十碳五烯酸（Eicosapentaenoic acid，EPA）;二十碳五烯酸, C20:5w3;二十碳双烯酸;附子脂酸;附子脂酸, C20:5w3 C22:6w3;DHA;二十二碳六烯酸（Docosahexaenoic acid，DHA）;二十二碳六烯酸, C22:6w3;二十二碳六烯酸 w3 二十碳五烯酸（附子脂酸、EPA、C20:5w3）+二十二碳六烯酸（DHA、C22:6w3、二十二碳六烯酸 w3） 克分子分数;摩尔分数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 类脂化合物;类脂物;脂类;脂肪酸;脂质 脂肪酸.C14-C24 血清或血浆

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88998-0