Version 2.78

Part Descriptions

LP266978-8   100 Cells.CD19
The CD19+ B cells are 95 kilo Dalton transmembrane glycoproteins and are comprised of a single transmembrane domain, a cytoplasmic C-terminus, and an extracellular N-terminus. It is a biomarker for normal and neoplastic B cells and for dendritic cells. CD19+ B cells regulate signaling thresholds by modifying B cell receptor dependent and independent signaling, functioning as a dominant piece of a multimolecular complex that resides on the mature B cell surface. The concentration of CD19 on the surface of B cells is tightly controlled throughout the cell's development, making it a very valuable biomarker for B cells. Mature B cells have three times the number of CD19 antigens than immature B cells, and when B cells differentiate into plasma cells, the expression of CD19 is lost. Patients who lack sufficient CD19 antigens have a lower response to transmembrane signals and weak T cell dependent antibody responses. CD19 is highly conserved and expressed in most B cell malignancies including acute lymphocytic leukemia, B cell lymphoma, and B cell leukemia. Efforts are in play to utilize CD19 antibodies for the treatment of lymphoma, leukemia, and autoimmune disorders. PMID: 23210908 Source: Regenstrief LOINC

LP20029-2   CD21
Found on mature B-cells.
Associated with some mature B-cell neoplasms, including B-cell CLL and Follicular lymphoma Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD21-/100 Cells.CD19
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
CD21- cells/100 CD19 cells NFr Bld
Display Name
CD21- cells/100 CD19 cells (Bld)
Consumer Name Alpha Get Info
CD21- cells per 100 CD19 Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
90414-4 B-cell phenotyping panel - Blood
90416-9 Lymphocyte subset and B-cell phenotyping panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Células CD21-/Porcentaje de células CD19:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD21- / 100 Cells.CD19:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD21-/100 cellules CD19:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD21-/100 Cellule.CD19:NFr:Pt:Sangue:Qn:
Synonyms: 100 cellule CD19 Cellule CD19 Cellule CD21 Cellule CD21- Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
zh-CN Chinese (China) 细胞.CD21-/100 个细胞.CD19:计数型分数:时间点:全血:定量型:
Synonyms: B2 B-2 B4;B-4;HD-37;Leu12;Leu-12 C3d 受体 CD19细胞 CD21细胞 CR2 EBV-R Epstein Barr 病毒受体（Epstein Barr virus receptor，EBV-R，EB 病毒受体） 发现于成熟 B-细胞之上。与某些成熟 B-细胞肿瘤相关，包括 B-细胞慢性淋巴细胞白血病以及滤泡性淋巴瘤。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89355-2