Version 2.80

Term Description

This terms was created for but not limited in use by TECHNOZYM vWF:CBA ELISA. The assay determines the adhesive properties of the vWF and its ability to bind to the collagen in the test wells. The OD of the bound vWF corresponds to the physiological function of the vWF.

Part Description

LP266353-4   von Willebrand factor collagen binding adhesion inhibitor
Von Willebrand disease (VWD) is caused by either a qualitative or quantitative deficit of the multimeric glycoprotein known as von Willebrand factor (VWF). VWD affects 1-2% of the world population, making it the most common inherited bleeding disorder. VWF plays a crucial role in primary hemostasis by triggering platelet adhesion to injured vessel walls and promoting platelet aggregation. VWF also protects factor VIII from premature degradation in the peripheral circulation. To diagnose VWD, there are several tests that must be run including Ristocetin cofactor activity, VWF antigen quantitative assay, Factor VIII activity, and collagen binding assay. Additional tests are needed to determine the subtype of VWD. The collagen binding assay measures the ability of VWF to bind to collagen by combining patient plasma with collagen that is adhered to a matrix. Then anti-VWF and dye are added in order to measure how much patient VWF combined to the collagen. When an antibody binds with an epitope on the VFW that is meant to bind to collagen, the ability of VWF to function is compromised. The collagen binding assay evaluates the functionality of the VWF, and is reduced in the presence of inhibiting anti-VWF antibodies. Patients who are most likely to develop anti-VWF include patients with complete or partial VWF gene deletions, patients who have received multiple transfusions, and patients with a family history of developing anti-VWF antibodies. PMID: 23297130 PMID: 21186048 Source: Regenstrief LOINC

Fully-Specified Name

Component
von Willebrand factor collagen binding adhesion inhibitor
Property
ACnc
Time
Pt
System
PPP
Scale
Qn
Method
Chromo

Additional Names

Long Common Name
von Willebrand factor collagen binding adhesion inhibitor [Units/volume] in Platelet poor plasma by Chromogenic method
Short Name
vWF CBA inhibitor PPP Chro-aCnc
Display Name
vWf collagen binding adhesion inhibitor Chromogenic method Qn (PPP)
Consumer Name Alpha Get Info
vWf collagen binding adhesion inhibitor, Blood

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
7129

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: vWF:CBA Inhibitor
el-GR Greek (Greece) αναστολέας πρόσφυσης κολλαγόνου παράγοντα Von Willebrand:ACnc:Pt:PPP:Qn:Chromo
Synonyms: ACnc αναστολέας πρόσφυσης κολλαγόνου παράγοντα Von Willebrand Κολλαγόνο παράγοντας Von Willebrand
es-ES Spanish (Spain) Inhibidor de la adherencia de unión al colágeno del factor von Willebrand:Concentración arbitraria:Punto temporal:Plasma pobre en plaquetas:Qn:Cromogénico ( Enzima)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Inhibidor de la adhesión de unión al colágeno del factor von Willebrand:Concentración arbitraria:Punto temporal:Plasma pobre en plaquetas:Cuantitativo:Cromogénico (enzima)
fr-FR French (France) Facteur Willebrand inhibiteur de liaison au collagène:Arbitraire/Volume:Ponctuel:Plasma pauvre en plaquettes:Numérique:Technique chromogénique
it-IT Italian (Italy) von Willebrand, fattore inibitore dell'adesione del collagene:ACnc:Pt:PPP:Qn:Cromo
Synonyms: Concentrazione Arbitraria Cromogenico (Enzima) Fattore di von Willebrand (vWf) Fattore von Willebrand inibitore dell''adesione del collagene Plasma povero di piastrine Punto nel tempo (episodio) Studio di coagulazione
zh-CN Chinese (China) von Willebrand 因子胶原结合黏附抑制剂:任意型浓度:时间点:贫血小板血浆:定量型:凝血因子酶学测定法
Synonyms: von Willebrand von Willebrand 因子（von Willebrand Factor，vWf）;vWf;vWf 因子;血管性假血友病因子;血管性血友病因子 von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）胶原（胶原蛋白）结合黏附（粘附）抑制剂（抑制因子、抑制物） 乏血小板血浆;Platelet poor plasma;PPP 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 冯·威勒布兰德 冯威勒布兰德 冯威勒布兰德氏 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 凝血因子发色测定方法;凝血因子发色测定法;凝血因子酶学测定方法;发色法;发色测定方法;发色测定法;显色法;显色测定方法;显色测定法;酶学法;酶学测定方法;酶学测定法;酶法 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 因素 抑制因子 抑制物 抑制物质 时刻;随机;随意;瞬间 系数 结合性 结合性的 胶原蛋白;胶原质;骨胶原

Example Units

Unit Source
[beth'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89366-9