Version 2.80

Description

Von Willebrand disease (VWD) is caused by either a qualitative or quantitative deficit of the multimeric glycoprotein known as von Willebrand factor (VWF). VWD affects 1-2% of the world population, making it the most common inherited bleeding disorder. VWF plays a crucial role in primary hemostasis by triggering platelet adhesion to injured vessel walls and promoting platelet aggregation. VWF also protects factor VIII from premature degradation in the peripheral circulation. To diagnose VWD, there are several tests that must be run including Ristocetin cofactor activity, VWF antigen quantitative assay, Factor VIII activity, and collagen binding assay. Additional tests are needed to determine the subtype of VWD. The collagen binding assay measures the ability of VWF to bind to collagen by combining patient plasma with collagen that is adhered to a matrix. Then anti-VWF and dye are added in order to measure how much patient VWF combined to the collagen. When an antibody binds with an epitope on the VFW that is meant to bind to collagen, the ability of VWF to function is compromised. The collagen binding assay evaluates the functionality of the VWF, and is reduced in the presence of inhibiting anti-VWF antibodies. Patients who are most likely to develop anti-VWF include patients with complete or partial VWF gene deletions, patients who have received multiple transfusions, and patients with a family history of developing anti-VWF antibodies. PMID: 23297130 PMID: 21186048 Source: Regenstrief LOINC

Basic Part Properties

Part Name
von Willebrand factor collagen binding adhesion inhibitor
Part Display Name
von Willebrand factor collagen binding adhesion inhibitor
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-03-01
Construct for LOINC Short Name
vWF CBA inhibitor

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP266353-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) von Willebrand 因子胶原结合黏附抑制剂
Synonyms: von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）胶原（胶原蛋白）结合黏附（粘附）抑制剂（抑制因子、抑制物）
es-ES Spanish (Spain) Inhibidor de la adherencia de unión al colágeno del factor von Willebrand
it-IT Italian (Italy) von Willebrand, fattore inibitore dell'adesione del collagene
Synonyms: Fattore von Willebrand inibitore dell''adesione del collagene
el-GR Greek (Greece) αναστολέας πρόσφυσης κολλαγόνου παράγοντα Von Willebrand
Synonyms: αναστολέας πρόσφυσης κολλαγόνου παράγοντα Von Willebrand