89502-9

SCL-70 extractable nuclear Ab [Units/volume] in Serum by Line blot

Active

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.

Part Description

LP16758-2 SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

LOINC Names Get Info

Fully-Specified Name: SCL-70 extractable nuclear Ab:ACnc:Pt:Ser:Qn:Line blot
Long Common Name: SCL-70 extractable nuclear Ab [Units/volume] in Serum by Line blot
Short Name: ENA Scl70 Ab Ser Line blot-aCnc
Display Name: SCL-70 extractable nuclear Ab Line blot Qn (S)
Consumer Name Alpha Get Info: SCL-70 extractable nuclear antibody, Blood

Part Model Get Info

Component
SCL-70 extractable nuclear Ab
LP39721-3
- Analyte
  SCL-70 extractable nuclear Ab
  LP39721-3
  - Component Numerator
    SCL-70 extractable nuclear Ab
    LP39721-3
    - Component Numerator Core
      SCL-70 extractable nuclear
      LP16758-2
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
Line blot
LP266806-1

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.68 (MIN)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG10098-8	SCL-70 extractable nuclear Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Antinukleární protilátky SCL-70 extrahovatelné:Arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Line blot
de-DE	German (Germany)	SCL-70 extrahierbarer nukleärer Ak:Arbiträre Konzentration:Zeitpunkt:Serum:Quantitativ:Line-Blot Synonyms: Scl-70
el-GR	Greek (Greece)	Εκχυλίσιμα πυρηνικά SCL-70 Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης Synonyms: ACnc Pt Qn SERO Αντίσωμα Γραμμή κηλίδωσης Εκχυλίσιμα πυρηνικά Εκχυλίσιμα πυρηνικά SCL-70 Ορός Πυρηνικό
es-ES	Spanish (Spain)	Antígeno nuclear extraíble SCL-70 Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Ab nuclear extraíble SCL-70:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FR	French (France)	SCL-70 Ac:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
fr-CA	French (Canada)	SCL-70 nucléaire soluble, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
it-IT	Italian (Italy)	Nucleare estraibile SCL-70 Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria ENA Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	SCL-70 extraheerbare nucleaire As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	SCL-70 rozpuszczalny jądrowy Ab:stężenie w jednostkach umownych:punkt w czasie:surowica:ilościowy:line blot Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
zh-CN	Chinese (China)	SCL-70 可提取性核抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体可提取性核抗原之抗体可用数量表示的;定量性;数值型;数量型;连续数值型标尺抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）时刻;随机;随意;瞬间核;胞核皮硬化症硬皮病硬皮病（Scleroderma，SCL）硬皮症线点杂交技术;线点杂交法;线条状印迹法细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.