Version 2.77

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Description

LP16760-8   Sjogrens syndrome-A extractable nuclear
Sjogren syndrome type A antigen (also known as SS-A, Ro, and E3 ubiquitin-protein ligase TRIM21) and Sjogren syndrome type B antigen (also known as SS-B and Lupus La protein) are nuclear antigens to which autoantibodies develop in autoimmune disorders such as Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). Between 40 and 70% of patients with SS have anti-SSA and/or anti-SSB autoantibodies, and 30-40% and 10-15% of patients with SLE are anti-SSA and anti-SSB positive, respectively. Longitudinal studies have shown that anti-SSA and -SSB antibodies may be present up to 20 years before the clinical onset of disease. SS patients who are anti-SSA and anti-SSB positive may have longer disease duration, parotid gland enlargement, decreased salivary flow, more severe minor salivary gland infiltration and a higher prevalence of extraglandular manifestations. PMID: 27184054 Source: Regenstrief LOINC, PMID: 27184054

Fully-Specified Name

Component
Sjogrens syndrome-A extractable nuclear Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Line blot

Additional Names

Short Name
ENA SS-A Ab CSF Ql Line blot
Display Name
Sjogrens syndrome-A extractable nuclear Ab Line blot Ql (CSF)
Consumer Name Alpha Get Info
Sjogrens syndrome-A extractable nuclear antibody, Spinal fluid

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG29303-1 Sjogrens syndrome-A extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Antígeno nuclear extraíble Síndrome de Sjogren-A (SS-A) Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot
es-MX Spanish (Mexico) Síndrome de Sjogrens:Ab nuclear extraíble:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal
fr-FR French (France) SSA/Ro anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
fr-CA French (Canada) Syndrome de Sjögren-a nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
it-IT Italian (Italy) Sjogren, sindrome-nucleare estraibile A Ab:PrThr:Pt:LCS:Ord:Line blot
Synonyms: anticorpo ENA Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant Sindrome di Sjorgen - nucleare estraibile A
nl-NL Dutch (Netherlands) SS-A extraheerbare nucleaire As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Zespół Sjogrena-A rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:płyn mózgowo-rdzeniowy:półilościowy:line blot
Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe
zh-CN Chinese (China) Sjogrens 综合征-a 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
Synonyms: A 型 Ab;自身抗体 ANA CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 ENA Ab ENA SS-A Ab ENA SS-A 抗体 ENA SS-A;Ro;Ro AB;Ro 抗体;Ro 抗原;Sjogren;Sjogrens 综合征-a ENA;Sjogrens 综合征-a 可提取性核 Ag;Sjogrens 综合征-a 可提取性核抗原;SSA;SS-A;干燥综合征-a 抗原 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA Ro AB Ro 抗体 Ro 抗原之抗体 Sjogren Ab Sjogren 抗体 Sjogren 氏综合征 Sjogren 综合征 Sjogren's 综合征 Sjogrens 综合征-a ENA Ab Sjogrens 综合征-a ENA 之抗体 Sjogrens 综合征-a ENA 抗体 Sjogrens 综合征-a 可提取性核 Ab Sjogrens 综合征-a 可提取性核 Ag Ab Sjogrens 综合征-a 可提取性核抗原之抗体 Sjogrens 综合征-a 可提取性核抗原抗体 SS SSA Ab SS-A Ab SSA 抗体 SS-A 抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 干燥综合征 干燥综合征（Sjogrens syndrome，SS） 干燥综合征-a Ab 干燥综合征-a 抗体 干燥综合征-a 抗原之抗体 干燥综合征-a 抗原抗体 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 线点杂交技术;线点杂交法;线条状印迹法 细胞核 Ab 胞核 Ab 胞核抗体 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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