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Part Description

LP269302-8   Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag:Imp:Pt:Bld:Nar:
Long Common Name
PNH GPI-Linked WBC and RBC Ag [Interpretation] in Blood Narrative
Short Name
PNH GPI-Linked WBC + RBC Ag Bld-Imp
Display Name
PNH GPI-Linked WBC and RBC Ag Nar (Bld) [Interp]
Consumer Name Alpha Get Info
Interpretation of PNH GPI-Linked White Blood Cells and Red Blood Cells antigen test result, Blood

Part Model Get Info

  • Component
    Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag
    LP269302-8
    • Analyte
      Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag
      LP269302-8
      • Component Numerator
        Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag
        LP269302-8
        • Component Numerator Core
          Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC
          LP269303-6
        • Component Numerator Core Suffix
          Ag
          LP20666-1
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    NULL
     

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)PNH GPI vázané erytrocyty a leukocyty Ag:Interpretace:Časový bod:Krev:Narativní:
el-GRGreek (Greece)Λευκά & Ερυθρά αιμοσφαίρια γλυκοσυλ-φωσφατιδυλοϊνοσιτόλη-εξαρτώμενης νυκτερινής παροξυντικής αιμοσφαιρινουρίας Αντιγόνο:Imp:Pt:Αίμα:Nar:
Synonyms: CELLMARK Imp Nar Pt Αίμα Αντιγόνο Λευκά & Ερυθρά αιμοσφαίρια γλυκοσυλ-φωσφατιδυλοϊνοσιτόλη-εξαρτώμενης νυκτερινής παροξυντικής αιμοσφαιρινουρίας
es-ESSpanish (Spain)WBC y RBC en Hemoglobinuria paroxística nocturna ligados a GPI Antígeno:Impresión/interpretación del estudio:Punto temporal:Sangre:Narrativo:
es-MXSpanish (Mexico)Hemoglobinuria paroxística nocturna WBC y Eritrocitos Ag ligados a GPI:Impresión / interpretación del estudio:Punto temporal:Sangre:Narrativo:
fr-FRFrench (France)Hémoglobinurie paraxystique nocturne GPI-Linked leucocytaire et érythrocytaire Ag:Interprétation:Ponctuel:Sang:Résultat textuel:
it-ITItalian (Italy)Parossismo notturno emoglobinuria, Ag:Imp:Pt:Sangue:Nar:
Synonyms: Impressione/interpretazione di studio Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
pl-PLPolish (Poland)Nocna napadowa hemoglobinuria GPI związane z WBC & RBC Ag:ocena:punkt w czasie:krew:opisowy:
Synonyms: Antygeny związane z GPI na WBC i RBC w napadowej nocnej hemoglobinurii Nocna napadowa hemoglobinuria GPI związane z leukocytami i erytrocytami
zh-CNChinese (China)阵发性睡眠性血红蛋白尿症 GPI-锚定白细胞与红细胞 抗原:印象:时间点:全血:叙述型:
Synonyms: Ag 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 细胞标志物 血;血液 阵发性睡眠性血红蛋白尿症（阵发性睡眠性血红蛋白尿、阵发性夜间血红素尿症、阵发性夜间血尿症、PNH） GPI-锚定（锚定型、链接型、连接型）白细胞（WBC）与红细胞（RBC）

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90739-4