90780-8
inFLIXimab Ab [Units/volume] in Serum by Immunoassay
Active
Part Descriptions
LP158087-9 inFLIXimab Ab
Antibodies to infliximab (ATI) are detectable in 20% of pediatric and young adult patients taking infliximab. Patients with ATI have reduced levels of infliximab and a higher risk for surgery in patient with inflammatory bowel disease (IBD). When treatment with infliximab is combined with immunomodulators, the likelihood of developing ATI is reduced when compared to using infliximab alone. PMID: 25569737
Source: Regenstrief LOINC
LP35095-6 inFLIXimab
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- inFLIXimab Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
- IA
Additional Names
- Long Common Name
- inFLIXimab Ab [Units/volume] in Serum by Immunoassay
- Short Name
- inFLIXimab Ab Ser IA-aCnc
- Display Name
- inFLIXimab Ab IA Qn (S)
- Consumer Name Alpha Get Info
- inFLIXimab antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.68 (MIN)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Ινφλιξιμάμπη Αντίσωμα: Synonyms: ACnc Ινφλιξιμάμπη |
| es-ES | Spanish (Spain) | Infliximab Anticuerpos: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | inFLIXimab Ab: |
| et-EE | Estonian (Estonia) | Infliksimaab antikehad: Synonyms: Juhuslik Kvantitatiivne Seerum |
| fr-FR | French (France) | Infliximab anticorps: |
| fr-BE | French (Belgium) | Infliximab Ac: Synonyms: Anticorps |
| fr-CA | French (Canada) | Infliximab, Ac: Synonyms: #REF! |
| it-IT | Italian (Italy) | Infliximab Ab: Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | infliximab As: Synonyms: antistof; |
| ru-RU | Russian (Russian Federation) | Инфликсимаб Ат: Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | İnfliksimab Ab: Synonyms: İmmünölçüm, immünoassay |
| zh-CN | Chinese (China) | 英利昔单抗 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |
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- CodeSystem lookup
- https:
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