Version 2.73

90829-3Glutamate decarboxylase 65 Ab [Units/volume] in Cerebral spinal fluid by Line blotActive

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. [PMID:7532143] GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years.[PMID:11114103] GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located.[PMID:22412264] Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases.[PMID:22405456] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief LOINC, Glutamate (Wikipedia)

Fully-Specified Name

Glutamate decarboxylase 65 Ab
Line blot

Additional Names

Short Name
GAD65 Ab CSF Line blot-aCnc
Display Name
Glutamate decarboxylase 65 Ab Line blot Qn (CSF)
Consumer Name Alpha
Glutamate decarboxylase 65 antibody, Spinal fluid

Basic Attributes

First Released
Version 2.65
Last Updated
Version 2.70
Order vs. Observation

Member of these Groups

LG50123-5 Glutamate decarboxylase 65 Ab|ACnc|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
谷氨酸脱羧酶-65 抗体:任意型浓度:时间点:脑脊液:定量型:线点印迹法
nl-NLDutch (Netherlands)
glutamaatdecarboxylase 65 As:eenheid/volume:moment:liquor cerebrospinalis:kwantitatief:lijnblot
fr-CAFrench (Canada)
Glutamate décarboxylase 65 , Ac:Concentration arbitraire:Temps ponctuel:LCR:Quantitatif:Immunoessai sur bandelette
fr-FRFrench (France)
Glutamate décarboxylase 65 anticorps:Arbitraire/Volume:Ponctuel:Liquide céphalorachidien:Numérique:Blot en ligne
it-ITItalian (Italy)
Glutammato decarbossilasi 65 Ab:ACnc:Pt:LCS:Qn:Line blot
es-MXSpanish (Mexico)
Glutamato descarboxilasa 65 Ab:Concentración arbitraria:Punto temporal:Fluído espinal cerebral:Cuantitativo:Mancha de línea
es-ESSpanish (Spain)
Glutamato decarboxilasa 65 Anticuerpos:Concentración arbitraria:Punto temporal:Líquido Cefalorraquideo:Qn:Line blot

Example Units

Unit Source
[arb'U]/L Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info