PCA-Tr Ab [Presence] in Cerebral spinal fluid by Cell binding immunofluorescent assay
LP269367-1 CBA IFA
In cell binding assays or cell-based assays (CBA) also known as cell-based immunoassays, the DNA coding for a particular antigen is transfected into cultured cells, which are then used directly as substrate for antibody detection by immunofluorescence. The advantage of CBA IFA over conventional immunoassays is that purification and stability of the antigen is not required and they provide an in vivo substrate. Source: Regenstrief LOINC
LP31709-6 Purkinje cell cytoplasmic type Tr
Purkinje cell cytoplasmic-Tr (PCA-Tr) antibodies are associated with Hodgkin's lymphoma. The clinical presentation that corresponds with PCA-Tr antibodies includes paraneoplastic cerebellar degeneration (PCD) and limbic encephalopathy (LE).[PMID: 22412264] PCD and LE are types of paraneoplastic neurological syndrome (PNS), an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. The antibodies that attack the neural tissue develop in response to tumor cells. The neurological symptoms include encephalitis, autonomic failure, peripheral neuropathy, cerebellar ataxia, visual complaints and more. The neoplasm may or may not be detectable using conventional imaging modalities. Since PNS can be associated with multiple antibodies, testing usually includes a panel of PNS antibodies. In addition, the different PNS antibodies are associated with certain cancers so the antibody pattern can assist in identifying the specific tumor if it was previously undiagnosed.[PMID: 22412264] Source: Regenstrief LOINC
- Purkinje cell cytoplasmic type Tr Ab
- CBA IFA
- Short Name
- PCA-Tr Ab CSF Ql CBA IFA
- Display Name
- PCA-Tr Ab Cell binding immunofluorescent assay Ql (CSF)
- Consumer Name Alpha
- PCA-Tr antibody, Spinal fluid
Example Answer List: LL2038-9Source: Quest Diagnostics Inc.
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
|IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)||LA11884-6|
- First Released
- Version 2.65
- Last Updated
- Version 2.69
- Order vs. Observation
Member of these Groups
|LOINC Group||Group Name|
|LG50127-6||Purkinje cell cytoplasmic type Tr Ab|
|zh-CN||Chinese (China)||浦肯雅细胞胞浆 Tr 型 抗体:
|it-IT||Italian (Italy)||Cellule di Purkinje tipo Tr Ab:
|fr-FR||French (France)||Tr anticorps:
|es-ES||Spanish (Spain)||Células de Purkinje tipo Tr Anticuerpos:
|es-MX||Spanish (Mexico)||Citoplasma de células de Purkinje tipo Tr Ab:
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